
NBS1 lactylation is required for efficient DNA repair and ... - Nature
2024年7月3日 · Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)-mediated DNA repair. Lactylation of NBS1 at lysine 388 (K388) is …
The role of NBS1 in DNA double strand break repair, telomere
2006年1月16日 · The NBS1 protein is a component of the MRE11/RAD50/NBS1 complex (MRN) that plays a critical role in the cellular response to DNA damage and the maintenance of …
NBS1 lactylation is required for efficient DNA repair and ... - PubMed
2024年7月4日 · Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)-mediated DNA repair. Lactylation of NBS1 at lysine 388 (K388) is …
NBS1 Heterozygosity and Cancer Risk - PMC - PubMed Central …
Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by chromosome instability and …
NBS1 and its functional role in the DNA damage response
NBS1 forms a multimeric complex with hMRE11/hRAD50 nuclease at the C-terminus and recruits or retains them at the vicinity of sites of DNA damage by direct binding to histone H2AX, which …
NBS1 and multiple regulations of DNA damage response - PMC
NBS1, a protein responsible for the radiation-sensitive autosomal recessive disorder Nijmegen breakage syndrome, is one of the first factors to accumulate at sites of DNA double-strand …
The NBS1–Treacle complex controls ribosomal RNA ... - Nature
2014年7月27日 · Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient …
NBS1 is required for macrophage homeostasis and functional …
2015年11月26日 · Our findings show that NBS1 is crucial for macrophage function during normal aging. These results have implications for understanding the immune defects observed in …
Functional Role of NBS1 in Radiation Damage Response and …
Nijmegen breakage syndrome (NBS) is a recessive genetic disorder characterized by increased sensitivity to ionizing radiation (IR) and a high frequency of malignancies. NBS1, a product of …
NBS1 is required for SPO11-linked DNA double-strand break
2020年1月21日 · Here, we show that MRN complex is essential for repairing meiotic SPO11-linked DSBs in male mice. In male germ cells, conditional inactivation of NBS1, a key …
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