Munc-18 (an acronym for mammalian uncoordinated-18) proteins are the mammalian homologue of UNC-18 (which was first discovered in the nematode worm C. elegans [1] [2]) and are a …

2019年9月23日 · Munc18-1 and Munc13-1 orchestrate SNARE complex formation by an NSF-SNAP-resistant mechanism 11 whereby Munc18-1 first binds to a self-inhibited “closed” …

Munc-18 is thought to serve multiple roles in exocytosis, the first being as an inhibitory protein which prevents assembly of the SNARE complex at inopportune times and which plays an …

Munc-18-1 regulates the initial release rate of exocytosis. Biophys J. 2008;94:1084–1093. doi: 10.1529/biophysj.107.111203. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]

Mammalian uncoordinated-18 (Munc 18) protein belongs to family of the Sec1/Munc18-like (SM) proteins. The Munc-18 protein is considered as essential component of trans-SNARE complex …

2019年1月8日 · Acceptor liposomes (Munc18-1/Syx1) contain 55% POPC, 20% POPE, 18% DOPS, 2% PIP2, and 5% DAG.

2017年11月30日 · Based on the reports of gene abnormalities including haploinsufficiency and heterozygous mutations, an essential role of MUNC-18-1 has been predicted in the etiology of …

Munc-18-1 is a 67-kDa neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis (Hata, Y., Slaughter, C. A., and Südhof, T. C. (1993a) Nature 366, 347 …

Munc-18-1 is crucial for vesicle exocytosis at presynaptic terminals (Verhage et al., 2000) and undergoes rapid PKC-catalyzed phosphorylation during the depolarization stage (Craig et al., …

Synaptic transmission of neuronal information is regulated by a series of key proteins, among which mammalian uncoordinated 18 (Munc18) is one class of the important proteins for …