The Role and Function of Mucins and Its Relationship to …
Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production.
Mucins, Mucus, and Goblet Cells - PubMed
The major macromolecular components of mucus are the mucin glycoproteins, which are critical for local defense of the airway. There are three classes of mucins in the airways: those that are secreted but do not polymerize (MUC7), those that are secreted and polymerize to form gels (MUC5AC, MUC5B), and those that have transmembrane domains and ...
Cellular and Molecular Biology of Airway Mucins - PMC
Airway mucus constitutes a thin layer of airway surface liquid with component macromolecules that covers the luminal surface of the respiratory tract. The major function of mucus is to protect the lungs through mucociliary clearance of inhaled foreign particles and noxious chemicals.
Immunological aspects of intestinal mucus and mucins
2016年8月8日 · In this Review, we will give a basic overview of mucus, mucins and goblet cells, and explain how each of these contributes to immune regulation in the intestine. Our bodies are continuously...
The biology of mucus: Composition, synthesis and organization
2018年1月15日 · Mucus is a complex aqueous fluid that owes its viscoelastic, lubricating and hydration properties to the glycoprotein mucin combined with electrolytes, lipids and other smaller proteins. Electron microscopy of mucosal surfaces reveals a highly convoluted surface with a network of fibers and pores of varying sizes.
Mucins, Mucus, and Sputum - CHEST
2008年2月14日 · Normal mucus and mucociliary clearance are critical components of lung innate immune function. Airway mucus maintains hydration in the airway and traps particulates, bacteria, and viruses. Mucus also has antioxidant, antiprotease, and antimicrobial activities.
Mucus and Mucins: The Underappreciated Host Defence System
2022年6月13日 · Mucin glycoproteins are a critical element of the mucosal barrier to infection. This barrier is dynamic and responsive to elements of both innate and adaptive immunity. It uses multiple defence mechanisms against microbes, including secreted mucus, the apical glycocalyx, and epithelial tight junctions.
Mucins: Structural diversity, biosynthesis, its role in …
2018年2月1日 · Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins.
Mucins, Mucus, and Goblet Cells - CHEST
2017年11月20日 · This review will focus on how airway mucus is organized in health and disease; how primary defects in cystic fibrosis (CF), asthma, and COPD alter mucin and mucous properties; and the growing body of evidence that mucins, mucus, and goblet cells are part of the innate immune system.
Mucus: Current Biology - Cell Press
2021年8月9日 · Mucus is a hydrogel that lines epithelial surfaces and serves as an interface with the external environment. In this Primer, McShane et al. introduce how mucins, the building blocks of mucus, are synthesized, how their expression is regulated and achieved, and how they make crucial contributions to health and disease.