The protein encoded by the Trim63 gene is also called MuRF1. MuRF1 is the name most commonly used in the literature, and it stands for "Muscle RING Finger 1." Structurally, there are two closely related MuRFs, MuRF2 and MuRF3. These also have TRIM codes: MuRF2 is TRIM55; MuRF3 is TRIM54.

2019年5月1日 · The muscle RING-finger protein-1 (MuRF1) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRF1 gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression le …

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them …

Muscle-specific RING finger protein 1 (MuRF1), also named TRIM63, is a RING-type E3 ligase that aroused growing interest in the context of muscle atrophy.

MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that MuRF1 is preferentially expressed in type II muscle fibers. Five and 14 days after ...

2020年9月11日 · This review discusses data obtained on MuRF1, both in skeletal and cardiac muscles, over the past 20 years, regarding the structure, the regulation, the location and the different functions identified, and the first inhibitors reported, and aim to draw the picture of what is known about MuRF1.

2020年9月11日 · The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play important roles during skeletal muscle atrophy. Since then, numerous studies have been conducted to decipher the roles, molecular mechanisms and regulation of this enzyme.

2021年2月23日 · MuRF1 and MuRF2-KO (knockout) mice have elevated serum glucose, elevated triglycerides, and reduced glucose tolerance. In addition, MuRF2-KO mice have a reduced tolerance to a fat-rich diet.

2019年3月27日 · In the present study, we hypothesized that MuRF1, a key gene involved in skeletal muscle mass loss, and its close counterpart MuRF2 play a role in skeletal muscle regeneration.

MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that MuRF1 is preferentially expressed in type II muscle fibers. Five and 14 days after denervation, MuRF1 protein was further elevated but remained preferentially expressed in type-II muscle fibers.

2018年6月4日 · TRIM63 also known as muscle-specific RING finger protein-1 (MuRF1) is an E3 ubiquitin ligase that is expressed selectively in cardiac and skeletal muscles (Bodine et al., 2001).

MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy.

2024年3月1日 · The data presented here offers molecular insight into MuRF-induced ubiquitylation. We show that MuRF1 can interact with the UBE2D, E, N/V families and UBE2W during ubiquitylation. MuRF1 forms monoubiquitylation and creates K48- and K63-linked polyubiquitin chains in a UBE2 dependent manner.

2021年1月12日 · Muscle-specific overexpression of IKKβ in transgenic mice leads to severe muscle wasting mediated, at least in part, by the ubiquitin ligase MuRF1, but not by atrogin-1/MAFbx 71.

MURF1 Antibody detects endogenous levels of total MURF1 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MURF1 protein. Antibodies were purified by protein A and peptide affinity chromatography.

2021年5月19日 · MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy.

The hyperactivation of E3 ligases, particularly MuRF1, is implicated in skeletal muscle wasting, positioning MuRF1 as a target for therapeutic intervention. Inhibitors of MuRF1 function through 2 principal mechanisms.

2012年7月19日 · TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for subsequent degradation by the ubiquitin-proteasome system (UPS). To determine the pathogenic role of TRIM63 in human hypertrophic cardiomyopathy (HCM).

2009年6月4日 · Muscle ring finger (MuRF)1 is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates and heterodimerizes with MuRF1.

Muscle RING finger 1 (MuRF1) is a critical muscle-specific ubiquitin ligase associated with muscle atrophy. Yet, the molecular target of MuRF1 in atrophy and aging remains unclear. We examined the role of MuRF1 in aging, using MuRF1-deficient (MuRF1 -/- ) mice in vivo, and MuRF1-overexpressing cell in vitro.