High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. [5] [6]

2024年12月25日 · MS4A2 (Membrane Spanning 4-Domains A2) is a Protein Coding gene. Diseases associated with MS4A2 include Ige Responsiveness, Atopic and Allergic Asthma. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Innate Immune System.

Using immunohistochemistry, we validated that MS4A2, the beta subunit of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 gene expression is an independent prognostic marker for early-stage lung cancer patient survival.

The MS4A gene family encodes 18 tetraspanin‐like proteins, most of which with unknown function. MS4A1 (CD20), MS4A2 (FcεRIβ), MS4A3 (HTm4), and MS4A4A play important roles in immunity, whereas expression and function of other members of the family ...

2021年8月9日 · MS4A genetic polymorphisms have been associated with human diseases, such as neurodegeneration. Based on the success of anti-CD20/MS4A1 monoclonal antibodies in malignancy and autoimmunity, these proteins might represent putative targets for innovative therapeutic strategies.

2024年8月27日 · Using immunohistochemistry, we validated that MS4A2, the beta subunit of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 gene expression is an independent prognostic marker for early-stage lung cancer patient survival.

Gene ID: 14126, updated on 8-Feb-2025. This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine.

In humans and mice, CD20/MS4A1 is mainly expressed by B cells, MS4A2 by mast cells and basophils, and MS4A3 by progenitors of both myeloid and lymphoid lineages [2–5] within the hematopoietic compartment (Figure 1).

Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in positive regulation of mast cell degranulation; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of release of sequestered calcium ion into cytosol.

Distinct cytoplasmic expression in a subset of lymphoid cells. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas. All transcripts of all genes have been analyzed regarding the location (s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.