MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene. [5] [6] Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling ...

2021年6月10日 · MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network. To characterize all hematopoietic stem and progenitor cells, we performed RNA-sequencing (RNA-seq) analysis to identify specific transcriptomic landscapes of HSCs and MPP1-5.

2021年6月10日 · Upon transplantation, MPP5 supports initial emergency myelopoiesis followed by stable contribution to the lymphoid lineage. MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network.

2021年8月1日 · MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network. To characterize all hematopoietic stem and progenitor cells, we performed RNA-sequencing (RNA-seq) analysis to identify specific transcriptomic landscapes of HSCs and MPP1-5.

2020年10月10日 · Membrane Protein Palmitoylated 5 (MPP5), also known as Protein Associated with Lin7 (PALS1), is a highly conserved apical complex protein characterized by its asymmetric localization to the apical side of polarized cells (OMIM 606958).

This study provides a comprehensive analysis of the whole classically gated LSK compartment, focusing on the functional and molecular characteristics of the MPP5 subset.

Here we identified a member of the Pals1/MPP5 family, MAGU-2, that functions in the epidermis to modulate phagocytosis and the number of synapses by regulating ZIG-10 localization.