2021年4月12日 · A morpholino is a synthetic oligomer molecule that contains DNA bases on a methylene morpholine backbone. The name comes from morpholine oligomer.

Morpholino oligonucleotides are stable, uncharged, water‐soluble molecules used to block complementary sequences of RNA, preventing processing, read‐through, or protein binding at those sites. Morpholinos are typically used to block translation of ...

Morpholino antisense oligonucleotides are common used to transient knockdown of gene expression by blocking translation of a targeted protein. Morpholinos can be designed by Gene tools (Philomath, OR).

Morpholino oligonucleotides are stable, uncharged, water‐soluble molecules that bind to complementary sequences of RNA, thereby inhibiting mRNA processing, read‐through, and protein binding at those sites.

Morpholino-based oligomers are effective, stable and highly adaptable anti-sense DNA analogs for gene silencing and editing. The development of cell-penetrating modifications has greatly facilitated their applicability for in vivo use by permitting systemic …

2005年3月26日 · Morpholino is an antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of …

2017年3月2日 · Morpholino oligonucleotides are stable, uncharged, water-soluble molecules used to block complementary sequences of RNA, preventing processing, read-through, or protein binding at those sites.

Morpholino consists of 22–25 nucleotides and can be used to block translation, splicing, miRNAs, lncRNAs, ribozyme activity [111]. Morpholino oligos have methyl-enemorpholine rings that replace the ribose/deoxyribose sugar moieties along with non-ionic phosphorodiamidate linkages for replacement of the anionic phosphates of either DNA or RNA ...

2025年2月11日 · Explore the latest advancements in morpholino chemistry, focusing on synthesis, structural innovations, and hybridization mechanisms.

Gene Tools makes Morpholino antisense oligos. Morpholino oligos bind to complementary RNA and get in the way of processes; they can knock down gene expression, modify RNA splicing, or inhibit miRNA activity and maturation.