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Monocarboxylate transporter - Wikipedia
The monocarboxylate transporters, [1] or MCTs, are a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate, pyruvate, and ketones across biological membranes. [2]
Monocarboxylate Transporters (SLC16): Function, Regulation ...
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation.
Monocarboxylate Transporter - an overview | ScienceDirect Topics
Monocarboxylate transporters (MCTs) are membrane proteins responsible for the transport of lactate, pyruvate, and ketone bodies. There are mainly three MCT isoforms present in the brain, each of which displays a distinct cellular distribution.
The monocarboxylate transporter family--Structure and ...
Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane. There are four isoforms, MCTs 1-4, which are known to perform this function in mammals, each with distinct substrate and inhibit …
Clinical and Functional Relevance of the Monocarboxylate ...
The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes.
Monocarboxylate Transporters: Therapeutic Targets and ...
Solute carrier (SLC) transporters represent 52 families of membrane transport proteins that function in endogenous compound homeostasis and xenobiotic disposition, and have been exploited in drug delivery and therapeutic targeting strategies.
The monocarboxylate transporter family--role and regulation
Monocarboxylate transporter (MCT) isoforms 1-4 catalyze the proton-linked transport of monocarboxylates such as L-lactate across the plasma membrane, whereas MCT8 and MCT10 are thyroid hormone and aromatic amino acid transporters, respectively.