2024年12月25日 · MMP20 (Matrix Metallopeptidase 20) is a Protein Coding gene. Diseases associated with MMP20 include Amelogenesis Imperfecta, Hypomaturation Type, Iia2 and Hypomaturation Amelogenesis Imperfecta. Among its related pathways are Collagen chain trimerization and Matrix metalloproteinases.

Matrix metallopeptidase 20 (MMP20) is an evolutionarily conserved protease that is essential for processing enamel matrix proteins during dental enamel formation. MMP20 mutations cause human autosomal recessive pigmented hypomaturation‐type amelogenesis imperfecta (AI2A2; OMIM #612529).

2016年7月11日 · Matrix metalloproteinase-20 (MMP20) is expressed by ameloblasts in developing teeth and MMP20 mutations cause enamel malformation. We established a stably transfected Tet -Off Mmp20...

Significantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with advanced stages of …

2007年5月1日 · Matrix metalloproteinase-20 (MMP20; enamelysin) is important for proteolytic processing of extracellular matrix (ECM) proteins during the formation of enamel and plays a critical role in proteolytic processing of amelogenin (AMEL), the …

The MMP20 gene provides instructions for making a protein called enamelysin, which is essential for normal tooth development. Enamelysin is involved in the formation of enamel, which is the hard, white material that forms the protective outer layer of each tooth.

2015年3月20日 · HGNC Approved Gene Symbol: MMP20. Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38) : 11:102,576,832-102,625,332 (from NCBI) The matrix metalloproteinases (MMPs) are a group of structurally related zinc-dependent endopeptidases that mediate the degradation of extracellular matrix components.

Matrix metalloproteinase 20 (MMP20) and kallikrein-related peptidase 4 (KLK4) are secreted proteinases that are essential for proper dental enamel formation.

These data demonstrate that increased MMP20 activity in molars causes premature degradation of ameloblastin and inactivation of cofilin, which may contribute to pathological Wnt-mediated cell migration away from the enamel layer.

Matrix metalloproteinase 20 (MMP20; enamelysin) is expressed by ameloblasts during the secretory stage through the early to mid-maturation stage. Inactivating MMP20 mutations cause severe enamel malformation, termed amelogenesis imperfecta. Therefore, MMP20 is essential for proper enamel development.