The upstream regulatory region of the Mmp13 gene contains a number of transcription factor binding sites but it was recently discovered that there is a conserved forkhead response element (FHRE) consensus sequence for FOXO3a in the human, mouse and rat Mmp13 promoter.

基质金属蛋白酶（MMPs）种类及功能基质金属蛋白酶（MMPs），1962年首先被确定为一种胶原蛋白水解酶，在蝌蚪尾巴的吸收过程中导致ECM蛋白降解。属于metzincins超家族，是一类锌依赖性内肽酶，可降解ECM的各种蛋白质…

mmp13是分泌至胞外基质或胞外空间的蛋白，如果检测不到信号，推荐尝试选择超滤或硫酸铵沉淀对细胞培养液先进行浓缩再检测。 对于部分细胞，如人软骨肉瘤细胞，IL-1β诱导处理可增强MMP13的表达，有助于解决无信号或信号弱的问题。

The results are consistent with a strong correlation between expressions of TGFβ1 and MMP-13 in OA-affected cartilage that TGF-β can upregulate the levels of MMP13 primarily through the SMAD independent pathway, suggesting TGF-β switches from a protective role observed from in vitro studies to a negative factor in OA-affected cartilage .

Dec 25, 2024 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type . Among its related pathways are Gene expression (Transcription) and Collagen chain trimerization .

Jan 8, 2013 · Here, we tested the role of MMP13 using Mmp13 cKO mice and using a MMP13 inhibitor in a surgically induced OA mouse model. Our studies suggest that inhibition of MMP13 expression or activity could efficiently prevent and decelerate OA progression.

摘要. 基质金属蛋白酶-13(mmp-13)是一种胶原酶，通过裂解靶蛋白的肽键来调节细胞外基质(ecm)的降解，在骨关节炎发生发展过程中主要负责降解关节软骨中的Ⅱ型胶原。

Osteoarthritis (OA) is an age-related degenerative disease, which is characterized by chronic joint pain, inflammation and the damage of joint cartilage. At present, steroidal drugs and nonsteroidal anti-inflammatory drugs (NSAIDS), selective cyclooxygenase-2 (COX-2) …

Sep 21, 2020 · 基质金属蛋白酶13（mmp13）是基质金属蛋白酶家族的成员，研究表明mmp13参与与骨关节炎相关的 聚集蛋白聚糖 降解，骨关节炎软骨移植物中 ii型胶原蛋白 的裂解，以及肿瘤的进展和转移。

Anti-infection 抗感染; ADC Related 抗体偶联药物相关; Apoptosis 凋亡; Autophagy 自噬; Cell Cycle/DNA Damage 细胞周期/DNA 损伤; Cytoskeleton 细胞骨架; Epigenetics 表观遗传学; GPCR/G Protein G 蛋白偶联受体/G 蛋白; Immunology/Inflammation 免疫及炎症; JAK/STAT Signaling JAK/STAT 信号通路; MAPK/ERK Pathway MAPK/ERK 信号通路; Membrane …