During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly …

MMP由促炎细胞和子宫胎盘细胞分泌，包括成纤维细胞、 成骨细胞 、 内皮细胞 、血管平滑肌、巨噬细胞、中性粒细胞、淋巴细胞和细胞滋养细胞等。 真皮成纤维细胞和白细胞是MMP的主要 …

MMP13是基质金属蛋白酶（MMP）肽酶M10家族的成员，能够降解多种细胞外基质蛋白，包括原纤维胶原蛋白，纤连蛋白，腱糖蛋白-C（ Tenascin-C，TNC）和聚集蛋白聚糖（aggrecan …

Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the …

2024年12月25日 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and …

2020年9月21日 · 基质金属蛋白酶13（MMP13）是基质金属蛋白酶家族的成员，研究表明MMP13参与与骨关节炎相关的 聚集蛋白聚糖 降解，骨关节炎软骨移植物中 II型胶原蛋白 的裂 …

基质金属蛋白酶-13 (MMP-13)是一种胶原酶，通过裂解靶蛋白的肽键来调节细胞外基质 (ECM)的降解，在骨关节炎发生发展过程中主要负责降解关节软骨中的Ⅱ型胶原。 在软骨动态平衡过程 …

Matrix metalloproteinase-13 (MMP-13), an important member of matrix metalloproteinases (MMPs) family, plays a vital role by degrading type II collagen in articular cartilage and bone in …

2025年2月8日 · Knockdown of matrix metallopeptidase 13 (collagenase 3; MMP13) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a …

2023年2月13日 · Lausch et al. (2009) found that recessive metaphyseal anadysplasia (MANDP2) is caused by homozygous loss of function of MMP9, whereas dominant metaphyseal …

2021年2月9日 · Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive …

2013年1月8日 · In the present studies, we will determine the role of MMP13 in MLI-induced OA progression. We will use Col2CreER;Mmp13 fx/fx (Mmp13 Col2ER) mice to block Mmp13 …

2021年2月9日 · Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive …

2013年1月8日 · The purpose of this study was two-fold: 1) to investigate the role of MMP13 in the development of OA; and 2) to evaluate the efficacy of the MMP13 inhibitor CL82198 as a …

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival. Overview of MMP-13 as a Promising Target for the Treatment …

2018年4月1日 · MMP13, one amongst the MMPs plays a premier role in bone remodeling, and mutations in MMP13 have been implicated in various pathologies including cancer and …

2023年3月2日 · We demonstrate that DCIS-associated myoepithelial cells promote striking myoepithelial-led invasion of luminal cells, mediated by the collagenase MMP13 through a non …

Matrix metalloproteinase-13 (MMP-13) was identified as a common up-regulated gene by cancer invasion-related factors. Although MMP-13 slightly promoted tumor invasion, we found that …

2017年11月10日 · In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream …

2025年2月8日 · MMP13 is a marker of carcinoma-associated myofibroblasts of invasive carcinoma, but it does not make a major contribution to tumor progression in the mouse model …