May 5, 2021 · Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the …

In this review, we discuss the key steps that lead to MLKL activation, possible models that explain how it becomes the death executor in necroptosis, and its emerging alternative functions.

Jun 19, 2020 · Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to...

Dec 25, 2024 · MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Diseases associated with MLKL include Maturity-Onset Diabetes Of The Young and …

The pathophysiological actions of MLKL in the lysosome and endosome. (A) MLKL translocates to the lysosomal membrane, triggering lysosome aggregation and fusion and ultimately leading …

Analysis of MLKL expression patterns reveals that MLKL is upregulated by type I/II interferon, conditions of inflammation, and tissue injury. Overall, MLKL may affect cancer development …

Feb 8, 2025 · MLKL: Functions beyond serving as the Executioner of Necroptosis. RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus …

Here, I review our current understanding of how MLKL is activated by the upstream receptor interacting protein kinase (RIPK)3, the proposed mechanism (s) by which MLKL kills cells, and …

Jul 18, 2017 · Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …

Mar 4, 2021 · Pseudokinase mixed lineage kinase domain-like protein (MLKL) serves as a terminal-known obligate effector in the process of necroptosis. To date, the majority of …