Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. [5] This gene belongs to the protein kinase superfamily. The encoded protein …

mlkl是tnf（肿瘤坏死因子）诱导的坏死性凋亡过程中的关键靶标，它作为ripk1和ripk3下游的效应蛋白发挥作用。 RIPK3在Ser227位点被磷酸化，此磷酸化为MLKL激活所必需。

磷酸化修饰的MLKL（p-MLKL）是坏死性凋亡的触发因素。它不存在于正常组织中，只能在感染、细胞受损或老化组织中检测到。 蛋白表达 MLKL激活后会形成同源三聚体。 p-MLKL需要坏死 …

ripk1、ripk3 和 mlkl 是参与坏死性凋亡的主要分子。 RIPK1 的激酶活性对于多种复合体至关重要，这些复合体能够调节炎症（复合体 I）、凋亡（复合体 IIa）和坏死性凋亡（复合体 IIb）。

2024年12月25日 · MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Diseases associated with MLKL include Maturity-Onset Diabetes Of The Young and …

2021年5月5日 · Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the …

Mixed lineage kinase domain-like (MLKL) protein is the main player of this cell death pathway as it mediates the final step of plasma membrane permeabilization. Despite the significant progress …

2020年6月19日 · Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to...

2025年2月8日 · The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. Positive Charges in the Brace Region …

Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the hallmarks of …