2024年12月25日 · MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with MKNK1 include Glioma Susceptibility 1 and Leukemia, Acute Myeloid. Among its related pathways are Negative regulation of …

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. [5] [6]

MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis. MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.

The Mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs), serine/threonine kinases encoded on two genes (MKNK1 and MKNK2), were identified simultaneously in mice and in humans in 1997. In humans, each gene gives rise to two isoforms from an alternatively spliced transcript, named MNK1a/MNK1b and MNK2a/MNK2b [ 3 , 4 ] ( Figure 1 ).

2023年11月23日 · Title: MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis. MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.

Mnk1 is activated in response to treatment with growth factors, ultraviolet (UV) radiation, mitogens and stress inducing agents such as anisomycin or sorbitol as well as by cytokines such as type I and type II interferons (IFNs), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, etc. [3 - 6].

2023年4月1日 · MNK1 and MNK2 mRNA are expressed in virtually all sensory neurons in the human DRG and TG. MNK2 mRNA is more highly expressed in human DRG and TG nociceptors than MNK1. Inhibition of MNK1 and MNK2 would likely …

2024年3月5日 · This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G.

2024年10月23日 · Furthermore, our study identified MKNK1 as a direct tRF‐16‐7X9PN5D target gene, and tRF‐16‐7X9PN5D regulates CRC cell's ability to grow, migrate, invade, and obtain radiation resistance via MKNK1.

MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence. MKNK1 shares homology with MAPKAPK2 (602006), MAPKAPK3 (602130), and p90(RSK) (see 601684).