MAPK kinase kinases (MKKKs) as a target class for small-molecule ...
2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the …
Role of mitogen-activated protein kinase kinase kinases in signal ...
2007年5月14日 · In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs as targets for therapeutic intervention in cancer and …
Organization and regulation of mitogen-activated protein kinase ...
1999年4月1日 · MKKs are characteristically dual specificity kinases which catalyze the phosphorylation of MAPKs on both tyrosine and threonine residues. The MKKs are …
MAPK kinase kinases (MKKKs) as a target class for small-molecule ...
2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the …
MAPK kinase kinases (MKKKs) as a target class for small ... - PubMed
Scaffolding proteins organize MKK-MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the scaffolded complex that …
Role of mitogen-activated protein kinase kinase kinases in …
2007年5月14日 · Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase network through which diverse stimuli regulate the spatio-temporal activities of complex …
Structure and dynamics of the MKK7–JNK signaling complex
2015年3月3日 · MKK7 activates the c-Jun N-terminal kinase (JNK) pathway and is the only MKK containing three motifs within its regulatory domain. Here we obtain a comprehensive picture …
signaling hubs’ that regulate the specificity of MAPK activation. In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs.
Mammalian MAP kinase modules: how to transduce specific signals
MAPK modules are composed of a cascade of three intracellular protein kinases (MKKK, MKK and MAPK) which are activated successively by phosphorylation events. They are used to …
The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase …
Mitogen-activated protein kinase (MAPK) signaling networks represent important means of signal transduction in plants and other eukaryotes, controlling intracellular signaling by linking …