Because of the increased awareness on the importance of metabolism and bioenergetics in a wide variety of human diseases, more and more mitochondrial DNA (mtDNA) studies are performed to study the link between mtDNA sequence variation and disease development.

2019年11月22日 · Next-generation sequencing (NGS) is a revolutionary sequencing technology for analyzing genomes. However, preprocessing methods for mitochondrial DNA (mtDNA) sequencing remain complex, and it...

DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification. Investigative Genetics. 2013;4(1):1–13. doi: 10.1186/2041-2223-4-26.

Researchers at Mount Sinai use Illumina sequencing to develop novel methods for studying mitochondrial DNA, piwi-interacting RNA, and T cell receptor repertoire diversity. Their goal is to unravel cancer, infertility, and autoimmune disease mechanisms.

Genes encoded in the mitochondrial DNA can be systematically targeted with this evaluated sequencing strategy. Furthermore, it can be helpful for population genetic and forensic applications where further information to the CR is required.

Next-generation sequencing (NGS) is a revolutionary sequencing technology for analyzing genomes. However, preprocessing methods for mitochondrial DNA (mtDNA) sequencing remain complex, and it is required to develop an authenticated preprocessing method.

Mitochondrial DNA whole genome sequencing detects pathogenic point mutations and single large-scale deletions with heteroplasmy levels in the mtDNA, that contribute to mitochondrial dysfunction. Nuclear gene variants that may cause mitochondrial dysfunction are …