Interactions between m6A modification and miRNAs in malignant …
Jun 9, 2021 · Recently, increasing evidence has shown that m6A modification plays a vital role in regulating miRNA biosynthesis. We, herein, have reviewed the enzyme system involved in …
Crosstalk Between m6A RNA Methylation and miRNA Biogenesis …
Oct 13, 2023 · In this review, we discuss various mechanisms by which m6A RNA methylation regulates miRNA biogenesis, the functional crosstalk between m6A RNA methylation and …
N6-methyl-adenosine (m6A) marks primary microRNAs for processing
By using an unbiased approach, we have identified m6A as a novel regulator of miRNA processing. Our findings reveal that METTL3 methylates primary inter- and intragenic …
Interactions between m6A modification and miRNAs in malignant tumors
Recently, increasing evidence has shown that m6A modification plays a vital role in regulating miRNA biosynthesis. We, herein, have reviewed the enzyme system involved in m6A …
m6A modification inhibits miRNAs’ intracellular function, favoring ...
Jun 25, 2024 · Here, we show that m6A modification on specific miRNAs weakens their coupling to AGO2, impairs their function on target mRNAs, determines their delivery into extracellular …
The role of m6A modification in the biological functions and
Feb 21, 2021 · The m6A-modified RNA reader proteins include YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, and HNRNPC/A2B1. m6A modification modulates miRNA biogenesis, XIST …
Effects of writers, erasers and readers within miRNA‐related m6A ...
As one of the most abundant post‐transcriptional mRNA modifications, N6‐methyladenosine (m6A) has attracted extensive attention from scientists. Emerging evidence indicates that m6A …
m6A modification inhibits miRNAs' intracellular function, favoring ...
Jun 25, 2024 · Here, we show that m6A modification on specific miRNAs weakens their coupling to AGO2, impairs their function on target mRNAs, determines their delivery into extracellular …
m6A RNA Methylation Is Regulated by MicroRNAs and Promotes ...
Mar 5, 2015 · We discovered that the m 6A formation of mRNAs is regulated by microRNAs (miRNAs) via a sequence pairing mechanism, and we revealed m6 A as a positive regulator …
Garbo et al. report that mature miRNAs are methylated (m6A) in a cell-specific manner and that highly methylated miRNAs are impaired in AGO2 association and in their intracellular function. …