2021年6月3日 · Midkine (MK或MDK)是一种 15 kDa的肝素结合分子，也被称为神经轴突生长促进因子2 ，是一种由 MDK基因 编码的蛋白。 Midkine具有多效性，能发挥细胞增殖、细胞迁移、血管生成和 纤维蛋白溶解等作用。这些患者的血清中 Midkine 浓度要比正常人高得多。

2019年12月4日 · Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor...

Midkine is a basic heparin -binding growth factor of low molecular weight, and forms a family with pleiotrophin (NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges.

2024年12月25日 · MDK (Midkine) is a Protein Coding gene. Diseases associated with MDK include Adenocarcinoma and Lymphoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and heparin binding. An important paralog of this gene is PTN.

2024年10月3日 · Midkine treatment mimics the effects of aging and promotes mammary tumorigenesis. Elevated midkine levels are associated with increased breast cancer risk in younger women highlighting its role in age-related tumor initiation.

2022年5月10日 · 研究人员进一步通过基因编辑手段及细胞生物学实验发现，通过Midkine调控LKB1-AMPK通路后能够促进癌症细胞增殖。临床数据分析显示，Midkine表达水平与AMPK的活性及病人生存率呈现负相关，证明了Midkine通过抑制LKB1-AMPK通路促进癌症的发展。

Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteoglycans. Midkine promotes migration, survival and other activities of target cells.

Midkine指的是人中期因子，一种化学物质。 近年来，有报道Midkine (MK)对肿瘤 新生血管 生成具有明显的调控作用。 在国内，MK与食管鳞癌血管生成的有关报道较少。 我们在对贲门癌血管生成及食管癌MK观察的基础上 [2,3]，应用免疫组化方法检测45例食管鳞癌组织中MK表达及与微血管密度的关系，初步探讨MK与血管生成的可能关系。 1 资料与方法. 1．1 资料 收集川北医学院附属医院病理科2003年1月～6月间具有完整临床病理资料的手术切除食管鳞癌45例。 男性35例，女 …

具体来说，Midkine通过激活PI3K-AKT-SREBF1信号通路，导致了乳腺上皮细胞的异常增殖和Aging-LP的出现。 这一发现为理解Midkine如何驱动衰老相关肿瘤提供 ...

Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at …