Mitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a central role in regulating mitochondrial fusion and cell metabolism. More specifically, MFN2 is a dynamin-like GTPase …

Dec 25, 2024 · MFN2 (Mitofusin 2) is a Protein Coding gene. Diseases associated with MFN2 include Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy and Charcot …

Feb 28, 2018 · Here we review the structural and functional properties of Mitofusin 2, highlighting its crucial role in several cell pathways, as well as in the pathogenesis of neurodegenerative …

Feb 18, 2005 · MFN2 hereditary motor and sensory neuropathy (MFN2-HMSN) is a classic axonal peripheral sensorimotor neuropathy, inherited in either an autosomal dominant (AD) manner …

Mfn2 regulates the expression of calcium exchange-related MAM proteins in the hippocampus tissues from Mfn2 cKO and Mfn2 overexpressing mice. (A,B) Representative western blot (A) …

In this review, we summarize the current knowledge of the structural and functional properties of Mfn2 as well as its regulation in different tissues, and also discuss the consequences of …

Feb 10, 2025 · Here we identify a role of MFN2 in quality control independent of its function in organellar shape remodeling. MFN2 ablation alters the cellular proteome, marked for example …

The MFN2 gene provides instructions for making a protein called mitofusin 2. This protein helps determine the shape and structure (morphology) of mitochondria, the energy-producing …

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation. Mycobacterium tuberculosis infection up-regulates MFN2 expression to promote NLRP3 …

Jun 21, 2024 · Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial …