Mitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a central role in regulating mitochondrial fusion and cell metabolism. More specifically, MFN2 is a dynamin-like GTPase embedded in the outer mitochondrial membrane (OMM) which in turn affects mitochondrial dynamics, distribution, quality control, and function.

2024年12月25日 · MFN2 (Mitofusin 2) is a Protein Coding gene. Diseases associated with MFN2 include Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy and Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2A2a. Among its related pathways are Selective autophagy and Mitophagy.

mfn2影响线粒体-er栓系，在ca2+信号转导中发挥关键作用，并在心肌组织和骨骼肌中高表达。 MFN2的突变能够导致20%的腓骨肌萎缩症，而MFN1的突变并没有引起疾病，这一事实也清楚地表明了功能上的差异。

2018年2月28日 · MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function.

Mfn2 regulates calcium exchange-related MAM proteins in stable SH-SY5Y cells with manipulated Mfn2 expression. (A,B) Representative western blot (A) and quantitative analysis (B) of MAM proteins in the total lysates of negative control (NC) and Mfn2 KO SH-SH5Y cells.

Mfn2基因位于1号染色体短臂lp36.22位置上，编码一种线粒体膜蛋白，参与线粒体的聚集和融合，并有助于线粒体网络的维持和运行 。

Mitofusin‐2 (Mfn2) regulatory pathway. Peroxisome proliferator‐activated receptor gamma coactivator 1α (PGC‐1α) and PGC‐1β are positive regulators of Mfn2 activity. Mfn2 is induced by PGC‐1α in response to exercise, cold exposure or β3 adrenergic agonists, whereas under basal conditions PGC‐1β activates Mfn2.

2025年2月10日 · Restoring MFN2 levels re-establishes proteostasis in MFN2-KO cells and rescues fusion defects of MFN1-KO cells.

线粒体融合蛋白2(mitofusin 2,Mfn2)位于线粒体外膜上,是线粒体外膜融合的重要蛋白之一。 研究发现,它不仅参与调控线粒体形态结构,还与细胞代谢、增殖、凋亡密切相关。

研究团队利用高脂饮食（HFD）诱导的肥胖小鼠模型和原代培养的心肌细胞，通过Mfn2的过表达和敲除、免疫共沉淀、免疫荧光等实验，研究了Mfn2与Hsc70在MLC形成中的相互作用及其对脂肪酸从脂滴到线粒体转移的影响。