DNA methylation patterns can be inherited and influenced by the environment, diet and aging, and disrupted in diseases. Complete DNA methylomes for several organisms are now …

Methylome represents the information of DNA methylation of all cytosines in a genome. The first WGBS study in 2008 reported the bulk methylation level within the CG, CHG, and CHH …

2023年1月4日 · Here we describe a human methylome atlas, based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis across thousands of unique markers for …

2022年5月2日 · We detail the evidence linking DNA methylation to ageing phenotypes and the longevity strategies aimed at altering both DNA methylation patterns and machinery to extend …

DNA methylation, the chemical process that adds a methyl group to DNA, is the principal manner in which genes are transcriptionally repressed or silenced. This modification occurs specifically …

Here, we review current and emerging technologies that hold promise to deliver the first mammalian methylome and to facilitate comprehensive profiling of essentially any cell type in …

MethBase allows researchers to easily access pre-computed methylome features and meta-information specific to WGBS experiments. As the number of methylomes analyzed grows, …

Methyl-binding protein domains and improved antibodies with broad specificity for methylated proteins are being used to characterize the “protein methylome”. They also have the potential …

2025年1月28日 · We performed whole-genome bisulfite sequencing on long-lived men (LLMs), long-lived women (LLWs), younger men (YMs) and younger women (YWs) to explore specific …

2022年12月15日 · In this Review, we focus on the mechanisms and functions of regulated DNA methylation and demethylation, highlighting how these dynamics, together with crosstalk …

2023年1月16日 · A study in Nature reports comprehensive, genome-wide mapping of the human methylome that provides mechanistic insights into gene regulation and offers great potential …

2008年5月1日 · Here, we review current and emerging technologies that hold promise to deliver the first mammalian methylome and to facilitate comprehensive profiling of essentially any cell …

2011年10月1日 · We use insights from the methylome of honeybees ( Apis mellifera) to emphasize the possible importance of organismal life histories in explaining methylation usage …

Here, we review current and emerging technologies that hold promise to deliver the first mammalian methylome and to facilitate comprehensive profiling of essentially any cell type in …

Therefore, the methylome – a genome’s collection of methyl marks – is a changeable snapshot of an organism’s (or a population’s) genomic response to its environment. Historically, whole …

DNA methylation is a highly conserved epigenetic modification that plays essential roles in mammalian gene regulation, genome stability and development.

2023年12月11日 · Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori

We investigated population evolutionary dynamics through phylogenetic and pangenome analyses. Additionally, we identified genome rearrangements and assessed the impact of …

We sought to examine the effects of changes in the intrauterine environment that occur across the first–second trimester transition on the placenta at the levels of the transcriptome and …

2024年8月12日 · We investigated population evolutionary dynamics through phylogenetic and pangenome analyses. Additionally, we identified genome rearrangements and assessed the …