
MERTK Gene - GeneCards | MERTK Protein | MERTK Antibody
2024年12月25日 · MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Retinitis Pigmentosa. Among its related pathways are GPCR Pathway and ERK Signaling.
MERTK - Wikipedia
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. [5][6][7] This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain.
Immunity | 一种全新的肿瘤免疫逃逸机制 - 知乎 - 知乎专栏
MerTK是在巨噬细胞上表达并具有促进吞噬作用的受体。细胞凋亡时会将磷脂酰丝氨酸(Phosphatidylserine, PtdSer)暴露于细胞表面,MerTK 借助桥梁分子 Gas6 或 Protein S 对PtdSer的识别而介导巨噬细胞对凋亡细胞的迅速吞噬和清除, 该过程被称为巨噬细胞的胞葬作用 ...
Mertk: An emerging target in cancer biology and immuno-oncology
Mertk, a type I Receptor Tyrosine Kinase (RTK) and member of the TAM (Tyro3, Axl, and Mertk) family of homologous tyrosine kinases, has important roles in signal transduction both homeostatically on normal cells as well as patho-physiologically on both tumor-associated macrophages and malignant cells by its overexpression in a wide array of ...
MERTK信号通路对细胞凋亡和免疫的作用过程 - 华美生物
2023年8月21日 · MERTK是一种受体酪氨酸激酶,参与调节多种生物学过程,特别是免疫和炎症反应、细胞凋亡和吞噬作用。 MERTK的信号通路主要涉及以下步骤: 1、结合配体:MERTK的配体主要是由凋亡细胞释放的胞噬脂(包括乳环磷酸酯和磷脂酰丝氨酸),以及其他未被清除的细胞碎片。 这些配体结合到MERTK受体上,引发其活化。 2、受体激活:配体结合后,MERTK受体发生构象变化,导致其激酶活性增强。 激酶活性的增强使得MERTK能够磷酸化其下游信号分子。 …
Focus on Molecules: MERTK - PMC
MERTK (UniProt accession Q12866) is a single pass transmembrane receptor that belongs to the TAM (T yro3, A xl and M ertk) family of receptor tyrosine kinases. MERTK is highly expressed in monocytes/macrophages, testis and epithelial cells including the retinal pigment epithelium (RPE) .
MerTK is a mediator of alpha-synuclein fibril uptake by human
2024年2月1日 · Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory, homeostatic phagocytosis of diverse types of cellular debris. Highly expressed on the surface of microglial cells, MerTK is of importance in brain development, homeostasis, plasticity and disease.
【Science子刊】华中科技大学陶娟团队:揭秘MerTK巨噬细胞在 …
2024年10月9日 · 已经开发了小分子MerTK抑制剂,用于EGFR突变非小细胞肺癌与奥希替尼的联合治疗,在人体1期试验中显示出逆转奥希替尼耐药性的有效性 (ClinicalTrials.gov, NCT04762199)。
MERTK- 信号通路|蛋白抗体-华美生物
在肿瘤微环境中,mertk的表达与肿瘤免疫逃逸有关,通过调节肿瘤相关巨噬细胞(tams)的吞噬作用,影响肿瘤免疫原性和抗肿瘤免疫。 MERTK是癌症治疗中一个潜在的药物靶点。
MerTK受体介导胞葬作用在ALI/ARDS中的研究进展
2022年8月27日 · MerTK受体是I型受体酪氨酸蛋白激酶,与同源受体Tyro3、Axl合称TAM受体家族,表达在所有组织的吞噬细胞如巨噬细胞、树突状细胞等细胞表面,此外肺血管内皮细胞上也有表达 。MerTK受体分为胞外区、胞内区和跨膜区。