2008年6月23日 · MED12-related disorders include the phenotypes of FG syndrome type 1 (FGS1), Lujan syndrome (LS), X-linked Ohdo syndrome (XLOS), Hardikar syndrome (HS), and nonspecific intellectual disability (NSID). FGS1 and LS share the clinical findings of cognitive impairment, hypotonia, and abnormalities of the corpus callosum.

2024年12月25日 · MED12 (Mediator Complex Subunit 12) is a Protein Coding gene. Diseases associated with MED12 include Opitz-Kaveggia Syndrome and Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Gene expression (Transcription).

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome. [5] Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer. [6]

MED12 （Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)）是在 X染色體 發現的人類 基因。 [6] MED12可與下列蛋白發生 相互作用： ^ 與MED12相關的疾病；在維基數據上查看/編輯參考. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference:.

2024年12月20日 · med12敲除在car-t细胞中促进了细胞适应性和肿瘤控制效果，可能通过改变激活状态的转变避免细胞进入完全静息或激活的峰值状态。 RNA-seq和Perturb-seq分析显示，MED12敲除的CAR-T细胞在刺激后表现出较低的激活水平和增殖比例，但静息状态下细胞增殖轻 …

The MED12 gene provides instructions for making a protein called mediator complex subunit 12. As its name suggests, this protein forms one part (subunit) of the mediator complex, which is a group of about 25 proteins that work together to regulate gene activity.

2022年11月25日 · 有研究发现中介复合体亚基12 （MED12）与中介复合体一起激活Wnt/β连环蛋白信号通路中的基因转录，调节抗肿瘤免疫。 而且也有研究发现中介复合体亚基12 （MED12）是中介转录调节复合体的组成部分，与DNA损伤修复（DDR）和TGF - β受体信号转导有关，但是癌症免疫治疗疗效和MED12突变之间的关系仍是不明确的。 近日， 先声诊断 与 南京鼓楼医院 、 大连医科大学附属第二医院 合作，于2022年10月在 European Journal of Medical Research …

Med12 is an X-linked gene that provides instructions for making a protein called Mediator complex subunit 12 (MED12). Mediator is a large multi-subunit complex that is critical for gene regulation. MED12 plays an important role in Mediator function by activating and repressing transcription through regulation of RNA polymerase II (1,2). The ...

该 Mediator 成分与 CDK8 亚复合物结合，CDK8 亚复合物包含由该基因编码的蛋白质、中介复合物亚基 12 (MED12) ，以及 MED13、CDK8 激酶和细胞周期蛋白 C。 CDK8 亚复合物调节 Mediator-聚合酶 II 相互作用，从而调节转录起始和再启动率。

2025年1月5日 · Gene target information for MED12 - mediator complex subunit 12 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.