2024年12月25日 · MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include Pheochromocytoma and Polydactyly-Macrocephaly Syndrome. Among its related pathways are Gene expression (Transcription) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor. [5][6] The protein product of MAX contains the basic helix-loop-helix and leucine zipper motifs. It is therefore included in the bHLHZ family of transcription factors.

2012年7月1日 · MYC-associated protein X (MAX) is a ubiquitous, constitutively expressed protein that plays a central role in controlling the MYC/MAX/MAX dimerization protein 1 (MXD1) axis, one of the better-known cellular networks whose deregulation contributes to the genesis of many human cancers.

2012年5月14日 · Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X), which predisposes carriers to PCC. How MAX mutations contribute to PCC/PGL and associated phenotypes remain unclear.

Myc 是一种与细胞增殖、分化和凋亡有关的癌蛋白。 同二聚体和异二聚体竞争共同的 DNA 靶位点 (E 盒) ，并且这些二聚体形式之间的重排提供了一个复杂的转录调节系统。 据报道，该基因的突变与遗传性嗜铬细胞瘤有关。 该基因的一个假基因位于 7 号染色体的长臂上。 可变剪接导致多个转录本变体。 [RefSeq 提供，2012 年 8 月] The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors.

Context: MYC-associated factor X (MAX) has been recently described as a new susceptibility pheochromocytoma (PHEO) gene with a total of ~40 reported cases. At present, no study has specifically described the functional imaging phenotype of MAX-related PHEO.

2021年3月25日 · Germline MAX mutations are associated with PCs, ganglioneuromas, neuroblastomas, pituitary neuroendocrine tumors, and, possibly, parathyroid adenomas, as well as nonendocrine tumors of chondrosarcoma and lung adenocarcinoma, suggesting MAX is a novel multiple endocrine neoplasia gene.

The MAX gene is a tumor suppressor gene that encodes for the MAX protein. MAX is involved in the MYC/MAX/MXD1 complex that is known to be involved in regulating cellular proliferation, differentiation and apoptosis.

2020年5月28日 · Max deletion increases growth and transformation in cells and dramatically accelerates SCLC progression in an Rb1/Trp53 -deleted mouse model. In contrast, deletion of Max abrogates tumorigenesis in MYCL-overexpressing SCLC. Max deletion in SCLC resulted in derepression of metabolic genes involved in serine and one-carbon metabolism.

By microarray analysis, Suzuki et al. (2016) showed identified Max as a suppressor of germ cell-related genes, as deletion of Max led to elevated expression of meiosis-related genes in mouse embryonic stem cells (ESCs). Immunocytochemical analysis revealed meiosis-like cytologic changes in Max-null ESCs.