
MAN1A1 Gene - GeneCards | MA1A1 Protein | MA1A1 Antibody
2024年12月25日 · MAN1A1 (Mannosidase Alpha Class 1A Member 1) is a Protein Coding gene. Diseases associated with MAN1A1 include Rafiq Syndrome and Congenital Disorder Of …
Prognostic relevance of the Golgi mannosidase MAN1A1 in
2019年10月29日 · Our study demonstrates the unfavourable prognostic role of MAN1A1 in ovarian cancer, probably caused by an altered ability of spheroid formation, and the strong …
MAN1A1 mannosidase alpha class 1A member 1 [ (human)]
Gene ID: 4121, updated on 8-Feb-2025. This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis …
Reduced mannosidase MAN1A1 expression leads to aberrant N …
2018年1月30日 · In vitro, reduced MAN1A1 expression or mannosidase inhibition led to a significantly increased adhesion of breast cancer cells to endothelial cells.
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月22日 · In this study, we report that Golgi α-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is phosphorylated at serine 12 …
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月22日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its …
Mannosidase, Alpha, Class 1 (MAN1A1 (Golgi Alpha ... - Springer
2014年1月1日 · Subsequent studies on the first of the mammalian α1,2-mannosidases to be characterized, termed Golgi α-mannosidase IA (MAN1A1), revealed a distinctive substrate …
MAN1A1 mannosidase alpha class 1A member 1 [ Homo sapiens …
2024年12月10日 · Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming …
MAN1A1 Gene: Function, Disorders, and Research - Mapmygenome
The MAN1A1 gene encodes a type II transmembrane protein, a class I mammalian Golgi 1,2-mannosidase. This enzyme catalyzes the removal of three specific mannose residues from …
Reduced mannosidase MAN1A1 expression leads to aberrant N …
Our study demonstrates the prognostic role of MAN1A1 in breast cancer by affecting the adhesive properties of tumour cells and the strong influence of this glycosylation enzyme on the …
Results: Patients with low/moderate MAN1A1 expression in tumours showed significantly shorter disease-free intervals than those with high MAN1A1 levels (P 1⁄4 0.005). Moreover, low …
In this study, we report that Golgi a-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is phosphorylated at serine 12 by CDK1 in mitosis, …
Gene: MAN1A1 (ENSG00000111885) - Summary - Homo_sapiens
A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月11日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its …
Genetic disruption of multiple α1,2-mannosidases generates …
In this study, we established cell lines with high-mannose–type N -linked, low-complexity glycans. We first knocked out two genes encoding Golgi mannosidases (MAN1A1 and MAN1A2) in …
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月22日 · Here, we performed phosphoproteomic studies of mitotic Golgi membranes and discovered that MAN1A1 is highly phosphorylated at serine 12 (S12) at its cytoplasmic …
Single-Cell RNA Sequencing Reveals the Cellular Origin and …
2021年5月15日 · Here, we performed single-cell RNA sequencing (RNA-seq) on 82,122 cells isolated from the breast cancer tissues and adjacent or prophylactic normal breast tissues …
CTSB is a negative prognostic biomarker and therapeutic target ...
2022年3月11日 · We found that CTSB was remarkably highly-expressed for HGG, IDH wild type, 1p19q non-codeletion type, MGMT promoter unmethylation type and mesenchymal gliomas. …
心肌细胞肥大的信号转导通路 - pku.edu.cn
心肌肥厚是肥大刺激诱导核内基因异常表达的结果,细胞内信号转导通路是肥大刺激与核内基因转录活化的偶联环节.然而,不同刺激诱导的心肌肥大可能具有不同的"分子表型",这主要取决于它们 …
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