
MAN1A1 Gene - GeneCards | MA1A1 Protein | MA1A1 Antibody
2024年12月25日 · MAN1A1 (Mannosidase Alpha Class 1A Member 1) is a Protein Coding gene. Diseases associated with MAN1A1 include Rafiq Syndrome and Congenital Disorder Of Glycosylation, Type In. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport.
MAN1A1 - Wikipedia
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene. [5] [6] This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein.
Reduced mannosidase MAN1A1 expression leads to aberrant N …
2018年1月30日 · In vitro, reduced MAN1A1 expression or mannosidase inhibition led to a significantly increased adhesion of breast cancer cells to endothelial cells.
MAN1A1 mannosidase alpha class 1A member 1 [ (human)]
Gene ID: 4121, updated on 4-Jan-2025. This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man (9)-GlcNAc (2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
MAN1A1 mannosidase alpha class 1A member 1 [ Homo sapiens …
2024年12月10日 · Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. Gonzalez DS, et al. J Biol Chem, 1999 Jul 23. PMID 10409699. What's a GeneRIF?
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月22日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its phosphorylation-deficient mutant in mitosis increases the formation of complex glycans.
MAN1A1 Gene: Function, Disorders, and Research - Mapmygenome
The MAN1A1 gene encodes a type II transmembrane protein, a class I mammalian Golgi 1,2-mannosidase. This enzyme catalyzes the removal of three specific mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to …
Reduced mannosidase MAN1A1 expression leads to aberrant N
2018年3月20日 · At an mRNA level, membrane proteins ALCAM and CD24 were only significantly prognostic in tumours with high MAN1A1 expression. In vitro, reduced MAN1A1 expression or mannosidase inhibition led to a significantly increased adhesion of breast cancer cells to endothelial cells.
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1
2022年11月11日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its phosphorylation-deficient mutant in mitosis increases the formation of complex glycans. Our study reveals that glycosylation is regulated by cytosolic signaling during the cell cycle.
Prognostic relevance of the Golgi mannosidase MAN1A1 in
2019年10月29日 · Our study demonstrates the unfavourable prognostic role of MAN1A1 in ovarian cancer, probably caused by an altered ability of spheroid formation, and the strong influence of this glycosylation ...