2024年12月25日 · MAN1A1 (Mannosidase Alpha Class 1A Member 1) is a Protein Coding gene. Diseases associated with MAN1A1 include Rafiq Syndrome and Congenital Disorder Of …

2019年10月29日 · Our study demonstrates the unfavourable prognostic role of MAN1A1 in ovarian cancer, probably caused by an altered ability of spheroid formation, and the strong …

Gene ID: 4121, updated on 8-Feb-2025. This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis …

2018年1月30日 · In vitro, reduced MAN1A1 expression or mannosidase inhibition led to a significantly increased adhesion of breast cancer cells to endothelial cells.

2022年11月22日 · In this study, we report that Golgi α-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is phosphorylated at serine 12 …

2022年11月22日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its …

2014年1月1日 · Subsequent studies on the first of the mammalian α1,2-mannosidases to be characterized, termed Golgi α-mannosidase IA (MAN1A1), revealed a distinctive substrate …

2024年12月10日 · Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming …

The MAN1A1 gene encodes a type II transmembrane protein, a class I mammalian Golgi 1,2-mannosidase. This enzyme catalyzes the removal of three specific mannose residues from …

Our study demonstrates the prognostic role of MAN1A1 in breast cancer by affecting the adhesive properties of tumour cells and the strong influence of this glycosylation enzyme on the …

Results: Patients with low/moderate MAN1A1 expression in tumours showed significantly shorter disease-free intervals than those with high MAN1A1 levels (P 1⁄4 0.005). Moreover, low …

In this study, we report that Golgi a-1,2-mannosidase IA (MAN1A1), the first enzyme that cargo proteins encounter once arriving the Golgi, is phosphorylated at serine 12 by CDK1 in mitosis, …

A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

2022年11月11日 · Expression of wild-type MAN1A1, but not its phosphomimetic mutant, rescues the glycosylation defects in mannosidase I-deficient cells, whereas expression of its …

In this study, we established cell lines with high-mannose–type N -linked, low-complexity glycans. We first knocked out two genes encoding Golgi mannosidases (MAN1A1 and MAN1A2) in …

2022年11月22日 · Here, we performed phosphoproteomic studies of mitotic Golgi membranes and discovered that MAN1A1 is highly phosphorylated at serine 12 (S12) at its cytoplasmic …

2021年5月15日 · Here, we performed single-cell RNA sequencing (RNA-seq) on 82,122 cells isolated from the breast cancer tissues and adjacent or prophylactic normal breast tissues …

2022年3月11日 · We found that CTSB was remarkably highly-expressed for HGG, IDH wild type, 1p19q non-codeletion type, MGMT promoter unmethylation type and mesenchymal gliomas. …

心肌肥厚是肥大刺激诱导核内基因异常表达的结果,细胞内信号转导通路是肥大刺激与核内基因转录活化的偶联环节.然而,不同刺激诱导的心肌肥大可能具有不同的"分子表型",这主要取决于它们 …