Macrophage differentiation and functional phenotypes. Macrophage polarization occurs through different activation programs by which macrophages carry out their defensive functions. In this …

2024年4月30日 · Macrophages are fully differentiated sentinels with a wired sensory array to sense extramural or danger signals through a plethora of receptors such as pattern recognition …

2019年3月20日 · Growth factors, such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and M-CSF play a principal role in their activation: GM-CSF drives the differentiation of …

Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into …

In this chapter we describe protocols to isolate human monocytes from peripheral blood mononuclear cell and how to differentiate them into macrophages by using growth factors …

Macrophages are terminally differentiated components of the mononuclear phagocyte system, which is composed of bone marrow-derived hematopoietic cells that give rise to monocytes …

2014年9月26日 · Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity …

2014年10月17日 · Macrophages are tissue sentinels that maintain tissue integrity by eliminating/repairing damaged cells and matrices. In this M2-like mode, they can also promote …

2022年1月1日 · A series of studies have described two distinct ways of macrophage differentiation mainly based on their origin and progeny. It is well accepted nowadays that MΦ …

2024年3月31日 · Macrophage differentiation is a multi-step process regulated by various signaling molecules and transcription factors. Additionally, they can present antigens from engulfed …