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  1. Dynamic fibroblast contractions attract remote macrophages in

    • Fibroblast contractions are sensed by other fibroblasts in the same fibrillar ECM13. To test whether mechanical communication through fibrillar ECM contributes to Mϕ attraction by contractile MFs, we firs… 展开

    Mϕ Actively Migrate Toward MFS on Collagen ECM

    To test whether MF-generated ECM deformations are detected by Mϕ, we added Mϕ (ratio 10:1) to MFs on collagen ECM after 1 h, followed by videomicroscop… 展开

    Nature
    ECM Structural Cues Are Insufficient to Attract Mϕ to MFS

    Previous studies have shown that monocytes can detect structural ECM cues, such as topographies, fibril alignments, and stiffness gradients18. To test the role of ECM structural c… 展开

    Nature
    Mϕ Follow Dynamic Pulling Events Transmitted Through ECM

    The fact that collagen fibril alignment was not conducive and even counterproductive for Mϕ attraction raises the question of the mechanical signal produced by MFs and sensed by distan… 展开

    Nature
    MF Remodeling Reaches Tensional Homeostasis

    To understand how increased ECM remodeling results in decreased attraction of Mϕ to MF, we analyzed the average ECM displacement magnitudes (Fig. 1e, analyzed by ring… 展开

    Nature
     
  1. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed displacements of collagen fibres.

    www.nature.com/articles/s41467-019-09709-6

    We present an integrated view of fibroblast-macrophage interactions that is centered on the CSF1-CSF1R axis and discuss how additional molecular programs linking these cell types can underpin disease onset, progression, and resolution.

    www.sciencedirect.com/science/article/pii/S107476…

    One central macrophage function in tissue repair and fibrosis is stimulating fibroblast-to-myofibroblast activation (Fig. 2 A, B).

    www.sciencedirect.com/science/article/pii/S094505…

    In this review, we focus on the effects of mechanical cues on macrophages and fibroblasts during FBR. We summarized the most current understandings and controversies of how macrophages and fibroblasts interact with different mechanical cues and the way they drive the fibrotic progression during FBR.

    www.sciencedirect.com/science/article/pii/S259000…

    In the current study, we successfully generated a practical and reliable human mast cell culture system with bone marrow CD34+ hematopietic precursors. The derivative mast cell is normal in terms of both morphology and function as manifested by normal degranulation.

    journals.plos.org/plosone/article?id=10.1371/journa…
  2. Fibroblast-macrophage reciprocal interactions in health, fibrosis, …

  3. The big five in fibrosis: Macrophages, myofibroblasts, matrix ...

  4. Macrophages and fibroblasts in foreign body reactions: How …

  5. The Role of Macrophage Migration Inhibitory Factor in Mast Cell

  6. Macrophages, Mastocytes, and Plasma Cells | SpringerLink

  7. Fibroblasts: Origins, definitions, and functions in health …

    2021年7月22日 · We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart.

  8. A macrophage-collagen fragment axis mediates subcutaneous

  9. The role of macrophage migration inhibitory factor in mast cell ...

  10. Fibroblasts and macrophages: Collaborators in tissue homeostasis ...