Myosin-7 is a protein that in humans is encoded by the MYH7 gene. It is the myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers). [5] This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α.

The MYH7 gene provides instructions for making a protein known as the beta (β)-myosin heavy chain. This protein is found in heart (cardiac) muscle and in type I skeletal muscle fibers. (Skeletal muscle are the muscles used for movement.)

2024年12月25日 · MYH7 (Myosin Heavy Chain 7) is a Protein Coding gene. Diseases associated with MYH7 include Myopathy, Distal, 1 and Congenital Myopathy 7B, Myosin Storage, Autosomal Recessive. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and PAK Pathway.

2016年7月7日 · Myosin heavy chain 7 (MYH7)-related myopathies are emerging as an important group of muscle diseases of childhood and adulthood, with variable clinical and histopathological expression depending on the type and location of the mutation.

Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described.

MYH7, encoding the myosin heavy chain sarcomeric β-myosin heavy chain, is a common cause of both hypertrophic and dilated cardiomyopathy. Additionally, families with left ventricular noncompaction cardiomyopathy (LVNC) and congenital heart disease (CHD), typically septal defects or Ebstein anomaly, …

2023年4月20日 · In this review, we summarized the structure of MYH7 and provide a brief overview of the relationship between the mutations in MYH7 and its disorders, as well as updating the latest research progress on diagnose methods and target therapy.

2021年5月14日 · About 30 years later, Christine Seidman and Jonathan Seidman 7 identified the first mutation in the gene encoding the MYH7 (myosin heavy chain 7) protein in the family that was described by Pare et al. The seminal discovery paved the way for partial delineation of the molecular genetic basis of HCM.

2025年3月4日 · Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle.

2015年11月15日 · Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in …