Mucin 5B - Wikipedia
Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene [5] [6] [7] [8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be …
MUC5B Gene - GeneCards | MUC5B Protein | MUC5B Antibody
2024年12月25日 · MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include Interstitial Lung Disease 2 and Extrinsic Allergic …
Muc5b overexpression causes mucociliary dysfunction and
2018年12月18日 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in …
MUC5B mobilizes and MUC5AC spatially aligns mucociliary
2022年11月25日 · Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Together, they form a hydrogel that can be actively transported by cilia along the …
Muc5b is required for airway defence - Nature
2013年12月8日 · Here we show that mouse Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis …
MUC5B - The New England Journal of Medicine
2018年10月20日 · The common gain-of-function variant rs35705950 16 in the promoter of MUC5B, encoding mucin 5B, is the strongest genetic risk factor for idiopathic pulmonary …
Localization of Secretory Mucins MUC5AC and MUC5B in …
2019年3月15日 · MUC5B and MUC5AC expression is a property of CCSP-positive secretory cells in superficial airway epithelia. In normal/healthy human airways, MUC5B is the dominant …
MUC5B mucin 5B, oligomeric mucus/gel-forming [ (human)]
2025年2月8日 · MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type …
MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities
2013年6月6日 · Recently, a single-nucleotide polymorphism (SNP) (rs35705950) in the promoter of the gene encoding mucin 5B (MUC5B) was shown to be associated with both familial …
Muc5b Is Required for Airway Defense - PMC - National Center for ...
2014年1月1日 · Here we show that Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in the …