Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. [5][6] The protein encoded by this gene is a member of the superfamily of ATP …

2024年12月24日 · ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, …

ABCC1 or multidrug resistance-associated protein 1 (MRP1) is a unidirectional efflux transporter with ubiquitous tissue distribution and wide substrate specificity including important therapeutics.

2009年8月12日 · MRP1 acts as an ATP-dependent efflux pump for the transport of organic anions, glutathione-, glucuronate-, or sulfate-conjugated drugs, or unconjugated drugs in …

2013年5月7日 · Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR), the regulatory mechanism of Mrp1 still remains unclear. Nrf2 …

MRP1 is known for its ability to actively decrease intracellular drug concentration, limiting the efficacy of cancer chemotherapy; however, data on the clinical relevance of MRP1 is …

2020年5月27日 · The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance energy transfer experiments, …

MRP1/ABCC1 (D5C1X) Rabbit mAb recognizes endogenous levels of total MRP1 protein. This antibody does not cross-react with MRP2 and MRP3 proteins. Monoclonal antibody is …

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …

2023年8月21日 · The Multidrug Resistance Protein 1 (Mrp1) is an ATP-dependent efflux transporter and a major facilitator of drug resistance in mammalian cells during cancer and …