MNK1 and MNK2 enforce expression of E2F1, FOXM1, and …
2021年2月9日 · In this study, we show that depletion of either MNK1 or MNK2 suppresses cell viability, anchorage-independent growth, and tumorigenicity of STS cells. We also identify a …
MKNK1 - Wikipedia
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. [5][6] MKNK1 has been shown to interact with MAPK1 [7] and Eukaryotic …
Role of MAPK/MNK1 signaling in virus replication - PMC
MAPK interacting kinase 1 (MNK1) has been shown to regulate both cap-dependent and internal ribosomal entry sites (IRES)-mediated mRNA translation. In this review we have discuss the …
Update on the Development of MNK Inhibitors as Therapeutic …
2022年1月27日 · Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2) represent a central class of enzymes that are activated by extracellular signal-regulated kinase …
丝裂素活化蛋白激酶（MAPK）与激酶1和2（MNK1和MNK2）相 …
背景：MNK1和MNK2是与MAP激酶相互作用的丝氨酸/苏氨酸激酶，被RAS和MAPK信号通路激活，并参与蛋白质翻译的调控。 两种激酶都会在保守的丝氨酸209上磷酸化翻译起始因子eIF4E …
Mnk kinase pathway: Cellular functions and biological outcomes
The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …
MKNK1 Gene - GeneCards | MKNK1 Protein | MKNK1 Antibody
2024年12月25日 · MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with MKNK1 include Glioma Susceptibility 1 and Leukemia, Acute …
Mnk2 and Mnk1 are essential for constitutive and inducible ...
Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases and implicated …
MNK1, a new MAP kinase-activated protein kinase, isolated by a …
1997年4月15日 · A novel clone isolated in this screen, designated MNK1, encodes a protein-serine/threonine kinase, which is most similar to MAP kinase-activated protein kinase 2 …
Discovery of Potent and Selective MNK Kinase Inhibitors for the ...
2025年3月4日 · We discovered a class of ether-containing compounds with a high MNK1/2 selectivity. These MNK inhibitors show good potency in reducing cell viability and colony …
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