During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis. [9]

MMP由促炎细胞和子宫胎盘细胞分泌，包括成纤维细胞、 成骨细胞 、 内皮细胞 、血管平滑肌、巨噬细胞、中性粒细胞、淋巴细胞和细胞滋养细胞等。 真皮成纤维细胞和白细胞是MMP的主要来源，尤其是MMP-2。 血小板是MMP-1、MMP-2、MMP-3和MMP-14的重要来源。 它们存在于大多数结缔组织中。 MMP-1、MMP-2、MMP-3、MMP-7、MMP-8、MMP-9、MMP-12、MMP-13以及MT1-MMP和MT3-MMP在各种血管组织和细胞中表达。 MMPs通常以非活性的proMMP形式分 …

MMP13是基质金属蛋白酶（MMP）肽酶M10家族的成员，能够降解多种细胞外基质蛋白，包括原纤维胶原蛋白，纤连蛋白，腱糖蛋白-C（ Tenascin-C，TNC）和聚集蛋白聚糖（aggrecan ，ACAN）。 MMP13可以切割三重螺旋胶原蛋白，其切割II型胶原蛋白的活性比切割I型和III型胶原蛋白高。 此外MMP13还能降解IV型，XIV型和X型胶原蛋白。 MMP13在多种生理过程，如伤口愈合、组织重塑、软骨降解、骨骼发育、骨矿化和骨化中发挥作用。 MMP13可能在细胞迁移和 …

Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.

2024年12月25日 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type. Among its related pathways are Gene expression (Transcription) and Collagen chain trimerization.

2020年9月21日 · 基质金属蛋白酶13（MMP13）是基质金属蛋白酶家族的成员，研究表明MMP13参与与骨关节炎相关的 聚集蛋白聚糖 降解，骨关节炎软骨移植物中 II型胶原蛋白 的裂解，以及肿瘤的进展和转移。 另外，MMP13还可以切割I，III，IV，IX，X和XIV型胶原蛋白和 纤连蛋白。 MMP13在细胞外基质降解和细胞-基质相互作用的调节中起关键作用。 我们使用明胶酶谱法检测了MMP13的活性。

基质金属蛋白酶-13 (MMP-13)是一种胶原酶，通过裂解靶蛋白的肽键来调节细胞外基质 (ECM)的降解，在骨关节炎发生发展过程中主要负责降解关节软骨中的Ⅱ型胶原。 在软骨动态平衡过程中，合成代谢反应 (如Ⅱ型胶原的产生)和分解代谢反应 (如MMP-13对软骨结构的破坏)的平衡有助于维持关节软骨的正常生理结构及功能，骨关节炎的软骨丢失通常是平衡失调所导致。 目前对影响骨关节炎发生发展的因素尚未完全了解，无早期骨关节炎的临床诊断和疾病治疗方案可用，鉴于此， …

Matrix metalloproteinase-13 (MMP-13), an important member of matrix metalloproteinases (MMPs) family, plays a vital role by degrading type II collagen in articular cartilage and bone in OA. It is noted that MMP-13 is specially expressed in the OA patients, and not in normal adults.

2025年2月8日 · Knockdown of matrix metallopeptidase 13 (collagenase 3; MMP13) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication

2023年2月13日 · Lausch et al. (2009) found that recessive metaphyseal anadysplasia (MANDP2) is caused by homozygous loss of function of MMP9, whereas dominant metaphyseal anadysplasia (MANDP1) is caused by missense mutations in the prodomain of MMP13; these mutations determine autoactivation of MMP13 and intracellular degradation of …

2021年2月9日 · Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.

2013年1月8日 · In the present studies, we will determine the role of MMP13 in MLI-induced OA progression. We will use Col2CreER;Mmp13 fx/fx (Mmp13 Col2ER) mice to block Mmp13 expression in chondrocytes and use MMP13 inhibitors to inhibit MMP13 activity.

2021年2月9日 · Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.

2013年1月8日 · The purpose of this study was two-fold: 1) to investigate the role of MMP13 in the development of OA; and 2) to evaluate the efficacy of the MMP13 inhibitor CL82198 as a pharmacologic treatment for preventing OA progression.

Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.

2018年4月1日 · MMP13, one amongst the MMPs plays a premier role in bone remodeling, and mutations in MMP13 have been implicated in various pathologies including cancer and arthritis. Transcriptional activation of MMP13 gene is tightly regulated by …

2023年3月2日 · We demonstrate that DCIS-associated myoepithelial cells promote striking myoepithelial-led invasion of luminal cells, mediated by the collagenase MMP13 through a non-canonical TGFβ – EP300...

Matrix metalloproteinase-13 (MMP-13) was identified as a common up-regulated gene by cancer invasion-related factors. Although MMP-13 slightly promoted tumor invasion, we found that MMP-13 was involved in tumor angiogenesis.

2017年11月10日 · In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy.

2025年2月8日 · MMP13 is a marker of carcinoma-associated myofibroblasts of invasive carcinoma, but it does not make a major contribution to tumor progression in the mouse model mammary cancer. Stronger Mmp-9 and -13 expression was detected in fracture calluses at day 7 in the juvenile compared to the middle-aged and elderly mice.