Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc and calcium endopeptidases. It can degrade a variety of extracellular matrix substrates and other substrates and plays important regulatory roles in many human pathophysiological processes.

High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct.

2024年12月25日 · MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Biliary Atresia and Rectum Cancer. Among its related pathways are Collagen chain trimerization and Matrix metalloproteinases. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity.

2019年11月1日 · Matrix metalloproteinase-7 (MMP-7) has been reported to be promising in diagnosing BA. We aimed to validate the diagnostic accuracy of MMP-7 for BA in a large population sample. We enrolled 288 patients with neonatal obstructive jaundice from March 2017 to October 2018. Serum MMP-7 levels were measured by using an enzyme-linked …

MMP-TIMP imbalance results in matrix proteolysis associated with various pathological processes such as tumor invasion. The present review discusses the involvement of two MMPs, MMP-2 and MMP-7, in cancer pathogenesis.

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation.

MMP-7, one of the best described biomarkers in IPF so far, is a member of the extensive MMP family, with the smallest molecular weight (247 amino acids). MMP-7 is expressed in alveolar macrophages and in alveolar and bronchiolar epithelial cells, and is known to degrade several ECM components.

Matrix metalloproteinase 7 is associated with clinical and pathological characteristics of salivary adenoid cystic carcinomas. MMP-7 expression is associated with a higher rate of tumor spread through air spaces in resected lung adenocarcinomas.

2022年9月22日 · Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1′ Subsite Binder with Short Peptides. Matrix metalloproteinase-7 (MMP-7) has emerged as a protein playing important roles in …

2013年10月16日 · In the small intestine, MMP7 is responsible for activating α-defensins, which are broad-spectrum anti-microbial peptides produced by the Paneth cells. We report that MMP7 −/− mice are...