DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is commonly associated with …

2023年7月12日 · If you both have a mutation in the MLH1 gene, there’s a chance your child could be born with a rare but serious condition called Constitutional Mismatch Repair Deficiency …

The MLH1 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in …

2024年12月25日 · MLH1 is a tumor suppressor gene involved in DNA mismatch repair. Germline mutations in this gene are known to cause Lynch syndrome. The most common malignancies …

2022年8月23日 · Studies show that men and women with an MLH1 mutation have between a 46 and 61 percent risk of developing colon or rectal cancer during their lifetime. Women with the …

2024年9月6日 · People with an inherited MLH1 mutation have an increased risk for many cancers, especially of the large intestine (the colon and the rectum) and uterus (endometrium). …

2024年8月29日 · People with an MLH1 mutation who have been diagnosed with cancer may benefit from biomarker testing and may qualify for clinical trials looking for more effective …

2025年2月20日 · MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue …

MLH1 is a gene that produces a protein involved in DNA repair, specifically in a process called mismatch repair. This protein works closely with other mismatch repair proteins, including …

The human-yeast hybrid genes MLH1_h(41-86) and MLH1_h(77-134) encode chimeric MLH1 proteins that contain 46 and 58 amino acid regions, respectively, of human MLH1p replacing …