
MAP2K4 - Wikipedia
Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. [5] MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli.
Mitogen-activated protein kinase kinase 4 (MKK4) - PubMed
The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines.
MAP2K4 Gene - GeneCards | MP2K4 Protein | MP2K4 Antibody
2024年12月25日 · MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.
First-in-class MKK4 inhibitors enhance liver ... - ScienceDirect
2024年3月28日 · MKK4 inhibition increased hepatocyte proliferation and liver regeneration upon hepatectomy in murine and porcine models and also revealed antisteatotic efficacy (mouse models of ASH and NASH), as well as antifibrotic efficacy in a CCl 4 liver damage mouse model. We are convinced that the observed antisteatotic and antifibrotic activity provides ...
首创新药MKK4抑制剂(HRX215)可显著增强肝再生并预防肝衰竭
近日,来自德国图宾根大学医院的 Lars Zender 团队在 Cell 杂志上发表一篇题为 First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure 的文章,他们在此 报告了首创新药MKK4小分子抑制剂HRX215的开发及功能表征,证明该药可预防肝切除术后肝衰竭 (PHLF ...
First-in-class MKK4 inhibitors enhance liver regeneration and …
2024年3月28日 · Here, we report on the structure-based development and characterization (nuclear magnetic resonance [NMR] spectroscopy) of first-in-class small molecule inhibitors of the dual-specificity kinase MKK4 (MKK4i).
MKK4 Inhibitors-Recent Development Status and Therapeutic …
2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways and therefore has a great impact on cell prolife …
MKK4 抑制剂——近期发展状况和治疗潜力 ... - X-MOL
MKK4(丝裂原活化蛋白激酶激酶 4;也称为 MEK4)是一种双特异性蛋白激酶,可磷酸化和调节 JNK(c-Jun N 末端激酶)和 p38 MAPK(p38 丝裂原活化蛋白激酶)信号通路,因此对细胞的增殖、分化和凋亡有很大的影响。
【Cell 】全新靶点MKK4 抑制剂已进入Ⅰ期临床试验,风险与机遇 …
2024年3月17日 · 德国图宾根大学 的 Lars Zender 团队在肝再生领域深耕十余年,2013 年曾在 Cell 报道通过体内 RNAi 筛选鉴定出丝裂原活化蛋白激酶激酶 4(MKK4)是肝细胞再生的关键调控因子。
MKK4 Inhibitors—Recent Development Status and Therapeutic
2023年4月19日 · MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal kinase) and p38 MAPK (p38 mitogen-activated protein kinase) signaling pathways and therefore has a great impact on cell proliferation, differentiation and apoptosis.