Jan 7, 2021 · Endothelial MEF2 (myocyte enhancer factor 2) activity is essential for vascular homeostasis and expression of Klf2 and Klf4 in the endothelium. MEF2 deficiency increases expression of YAP (yes-associated protein)/TAZ (transcriptional coactivator with PDZ-binding motif) target genes through increasing the amount of TAZ.

The MEF2 transcription factors have roles in muscle, cardiac, skeletal, vascular, neural, blood and immune system cell development through their effects on cell differentiation, proliferation, apoptosis, migration, shape and metabolism. Altered MEF2 ...

Dec 1, 2007 · We review the myriad roles of MEF2 in development and the mechanisms through which it couples developmental, physiological and pathological signals with programs of cell-specific transcription.

Myocyte enhancer factor 2 (Mef2) is a highly conserved transcription factor containing two key functional domains named MADS box and Mef2 domains. It plays a prominent role in the myogenic process by controlling the expression of many muscle genes in vertebrates and invertebrates [ 84 ].

The family of myocyte enhancer factor 2 (MEF2) transcription factors comprises four highly conserved members that play an important role in the nervous system. They appear in precisely defined time frames in the developing brain to turn on and turn ...

Apr 5, 2023 · Transcriptional regulators encoded by the M yocyte E nhancer F actor 2 (MEF2) gene family play a fundamental role in cardiac development, homeostasis and pathology. Previous studies indicate...

Myocyte enhancer factor–2 (MEF2) transcription factor belongs to the evolutionarily conserved cardiac gene regulatory network. Given its central role in muscle gene regulation and its evolutionary conservation, MEF2 is considered one of only a …

Recent studies have revealed multiple signaling systems that stimulate and inhibit myogenesis by altering MEF2 phosphorylation and its association with other transcriptional cofactors.

The Myocyte Enhancer Factor 2 (MEF2) proteins are transcription factors expressed during development of all three muscle lineages. Of the four mammalian mef2 genes, three (A, C and D) can be alternatively spliced, producing transcripts and proteins which may have significant functional differences. …

Feb 9, 2013 · The MEF2 (myocyte enhancer factor 2) family of transcription factors is composed of four distinct vertebrate genes. These factors were first identified in muscle but are also present in brain. MEF2 is involved in neuronal survival and is able to regulate the growth and pruning of neurons in response to stimulation.