Muscular Dystrophy Mouse Model Resource - The Jackson …
The Jackson Laboratory has a large collection of mouse models of muscular dystrophy. They are categorized below by specific disease type to help you easily find the best strain for your …
Humanizing the mdx mouse model of DMD: the long and the …
Feb 16, 2018 · Here we summarize the usefulness of the various commonly used DMD mouse models, highlight a model with shortened telomeres like humans, and identify directions that …
Animal models of Duchenne muscular dystrophy: from basic …
The most widely used animal model for DMD research is the mdx mouse. It was discovered in the early 1980s in a colony of C57BL/10ScSn mice due to elevated serum creatine kinase (CK) …
mdx mouse - Wikipedia
The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD). [1] [2] The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a …
Mouse models for muscular dystrophies: an overview - PMC
The most commonly used DMD model is the mdx mouse (Bulfield et al., 1984; Willmann et al., 2009) and, to a lesser extent, its genetic variants mdx 2cv, mdx 3cv, mdx 4cv, mdx 5cv (Cox et …
DMD Mouse Model - Neurology CRO - InnoSer
The mdx mouse model closely recapitulates the human DMD pathophysiological characteristics due to an X-linked mutation in the gene that encodes dystrophin in the skeletal muscle …
Humanization of the mdx Mouse Phenotype for Duchenne …
We focus on the DBA2/J strain-based D2.mdx mouse with heightened transforming growth factor (TGF)-β signaling and the dyslipidemic mdx/apolipoprotein E (mdx/ApoE) knock-out (KO) …
Duchenne Muscular Dystrophy Models | Charles River
What is the MDX mouse model? The X-linked muscular dystrophy (mdx) mouse model is used to study Duchenne muscular dystrophy. In this model, the dystrophin gene is truncated so the …
MDX mice for Duchenne’s - Charles River Laboratories
MDX Mice Models. Charles River has extensively validated a well-known model for Duchenne muscular dystrophy studies, the X-linked muscular dystrophy (MDX) mouse.
B10.mdx Physiological Data - The Jackson Laboratory
C57BL/10ScSn-Dmdmdx/J mice (001801), commonly called mdx, are the most published model of Duchenne’s muscular dystrophy. The mice carry a loss-of-function mutation in the …