Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene. [ 5 ] [ 6 ] [ 7 ] It is essential for activation of the Cdc45: Mcm2-7 : GINS helicase, and thus required for proper DNA replication.

2024年12月25日 · MCM10 (Minichromosome Maintenance 10 Replication Initiation Factor) is a Protein Coding gene. Diseases associated with MCM10 include Immunodeficiency 80 With Or Without Congenital Cardiomyopathy and Nk Cell Deficiency .

2023年10月17日 · Of the MCM protein family, MCM10 is a crucial member that maintains the stability and extension of DNA replication forks during DNA replication and is significantly overexpressed in a variety of...

2017年2月17日 · Mcm10 promotes the initiation of DNA replication through direct interactions with the cell division cycle 45 (Cdc45)-minichromosome maintenance complex proteins 2-7 (Mcm2-7)-go-ichi-ni-san GINS complex proteins, as well as single- and double-stranded DNA.

2025年2月8日 · High MCM10 expression is associated with lung adenocarcinoma. MCM10 is highly expressed in lung cancer (LC) clinical specimens and significantly associated with recurrence, pathological stage and worse overall survival.

Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function.

Mcm10 is required for DNA replication in all eukaryotes. While the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified ...

2024年5月31日 · Cryo-electron microscopy (cryo-EM) imaging of DNA replication origin activation explains the role of Mcm10, a minichromosome maintenance (MCM) protein homolog, during initiation. Mcm10...

2017年2月1日 · Our findings expand the roles of Mcm10 during DNA replication and suggest a new model for Mcm10 function as an activator of the CMG complex throughout DNA replication. Keywords: Cdc45/Mcm2–7/GINS; DNA replication fork; S. cerevisiae; cell cycle; reconstituted DNA replication.

2017年8月8日 · Here, we identified and characterized the Mcm2–7-interacting domain in human Mcm10. The interaction with Mcm2–7 required the Mcm10 domain that contained amino acids 530–655, which overlapped with the domain required …