Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene. [ 5 ] [ 6 ] [ 7 ] It is essential for activation of the Cdc45: Mcm2-7 : GINS helicase, and thus required for …

2024年12月25日 · MCM10 (Minichromosome Maintenance 10 Replication Initiation Factor) is a Protein Coding gene. Diseases associated with MCM10 include Immunodeficiency 80 With Or …

2023年10月17日 · Of the MCM protein family, MCM10 is a crucial member that maintains the stability and extension of DNA replication forks during DNA replication and is significantly …

2017年2月17日 · Mcm10 promotes the initiation of DNA replication through direct interactions with the cell division cycle 45 (Cdc45)-minichromosome maintenance complex proteins 2-7 (Mcm2 …

2025年2月8日 · High MCM10 expression is associated with lung adenocarcinoma. MCM10 is highly expressed in lung cancer (LC) clinical specimens and significantly associated with …

Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and …

Mcm10 is required for DNA replication in all eukaryotes. While the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA …

2024年5月31日 · Cryo-electron microscopy (cryo-EM) imaging of DNA replication origin activation explains the role of Mcm10, a minichromosome maintenance (MCM) protein homolog, during …

2017年2月1日 · Our findings expand the roles of Mcm10 during DNA replication and suggest a new model for Mcm10 function as an activator of the CMG complex throughout DNA …

2017年8月8日 · Here, we identified and characterized the Mcm2–7-interacting domain in human Mcm10. The interaction with Mcm2–7 required the Mcm10 domain that contained amino acids …