Chromosome 20 was nullisomic and X was disomic. The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene.

MCF-7 and MCF-10 are both cell lines used in breast cancer research, but they have distinct characteristics. MCF-7 cells are derived from metastatic breast adenocarcinoma tissue and are tumorigenic, while MCF-10 cells are derived from normal breast …

2012年4月26日 · MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].

The current paper provides a broad description of the MCF-7 cell line, including the molecular profile, proliferation, migration, invasion, spheroid formation, its involvement in angiogenesis and lymphangiogenesis and its interaction with the mesenchymal stem cells.

2015年3月31日 · MCF-7 as a Model of Response and Resistance to ER-Targeted Therapy. MCF-7 cells have served as a model for the study of estrogen response both in vitro and in vivo. The exact mechanism whereby estrogen stimulates MCF-7 …

Among many cell lines, the MCF-7 line has been widely used in in vitro breast cancer research worldwide for many years. It is positive for estrogen (ER), progesterone (PR), human epidermal growth (HER2), EGFR, and E-cadherin.

2012年4月4日 · Isolation and characterization of a tamoxifen-resistant cell line derived from MCF-7 human breast cancer cells. J. Biol. Chem. 256:5016-5021(1981) PubMed= 6582512 ; DOI= 10.1073/pnas.81.2.568 ; PMCID= PMC344720

The MCF-7 cell line is used by researchers throughout the world as a model of ER positive breast cancer and for characterization of antiestrogen response and resistance.

We have recently developed a protocol for MCF-7 cell spheroid culture, and used this method to test the effects of different types of drugs on this estrogen-dependent breast cancer cell spheroid. Our results demonstrated that MCF-7 cells can grow spheroid in …

2015年3月31日 · MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25000 scientific publications that used this cell line, how many know the unique story of its isolation and development?