The MCF 10A cell line is a non-tumorigenic epithelial cell line. The cells are positive for epithelial sialomucins, cytokeratins and milk fat globule antigen. They exhibit three dimensional growth in collagen, and form domes in confluent cultures.

2022年10月7日 · Here we focused on the well-characterized human mammary epithelial MCF10A cell line 40, 41, which is a nontransformed cell line that exhibits many of the key hallmarks of epithelial biology,...

MCF 10A cell lines are immortalized, non-tumorigenic epithelial cells derived from human breast tissue. They are extensively used as in vitro models to study breast tumor progression due to their close mimicry of normal breast epithelium and their ability to undergo oncogenic transformation.

Immortal human mammary epithelial cell lines. Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.

The human normal breast cell line MCF-10A is being widely used as a model in toxicity studies due to its structural similarity to the normal human mammary epithelium. Over the years, application of carbon dots (C-dots) in biomedicine has been ...

2015年7月6日 · MCF10A cells exhibit a unique differentiated phenotype in 3D culture which may not exist or be rare in normal human breast tissue. Our results raise a question as to whether the commonly used MCF10A cell line is a suitable model for human mammary cell studies.

MCF-10A cells are commonly recognized as a ‘‘normal’’ breast epithelial cell line, the karyotype is stable and near-diploid, these cells are nonetheless cytogenetically abnormal. These cells harbor a deletion of the locus containing p16 and p14ARF, as well as amplification of MYC. Notably, MCF-10A cells express wild-type p53.

MCF-10A, immortalized but non-transformed human breast epithelial cells, are widely used in research examining carcinogenesis. The studies presented here were initiated with the observation that MCF-10A cells left in continuous culture for prolonged ...

The MCF 10A ECAD-EmGFP reporter cell line provides a convenient and sensitive platform for research on the mechanisms of metastasis in vitro and the development of new antitumor drugs for metastatic breast cancer.

2025年3月14日 · Explore the biological complexity of MCF 10A cells, from growth behavior to epigenetic regulation and 3D culture applications in research. MCF 10A cells are a widely used, non-tumorigenic breast epithelial cell line that serves as a valuable model in cancer research and cellular biology.