Macrophage colony-stimulating factor (M-CSF) is a survival, growth, differentiation and activating factor for macrophages and their progenitor cells 1, 2. M-CSF is a complex cytokine, which can be produced as integral cell surface or secreted protein variants 3–6.

Macrophage colony-stimulating factor (M-CSF, also known as CSF-1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) drive the monocyte/macrophage development, differentiation, and proliferation along with cytokines such as …

2020年11月9日 · Transcriptomic analysis of LPS-stimulated M-CSF–derived human macrophages after the addition of exogenous Ado and PGE 2 reveals a modest but similar change in gene expression.

Macrophage colony-stimulating factor (M-CSF) is a bone marrow-derived glycoprotein that is capable of supporting the proliferation, maturation, and activation of cells of the mononuclear phagocyte lineage, 150, 151 and that has been approved for therapy in Japan.

2020年8月17日 · Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R. CSF1R-mediated signaling is crucial for the survival, function, proliferation, and...

M-CSF exhibits a mostly homeostatic expression pattern, whereas GM-CSF is a product of cells activated during inflammatory or pathologic conditions. Accordingly, M-CSF regulates the numbers of various tissue macrophage and monocyte populations without altering their "activation" status.

M-CSF stimulates differentiation of progenitor cells to mature monocytes, and prolongs the survival of monocytes. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis, and secondary cytokine production (G-CSF, IL-6, and IL-8) in monocytes and macrophages.

Primary human monocytes from healthy donors or SSc patients were differentiated into MDMs in vitro in the presence of GM-CSF (GM-MDM or GM-SSc) or M-CSF (M-MDM or M-SSc) for 6 days. Culture media were replaced between the 6th–7th day.

Here we review the biology of M-CSF, which has important roles in bone physiology, the intestinal tract, cancer metastases to the bone, macrophage-mediated tumor cell killing and tumor immunity.

2009年6月7日 · Here we show DAP12 deficiency impaired the M-CSF-induced proliferation and survival of macrophages in vitro. DAP12-deficient mice had fewer microglia in defined central nervous system areas,...