Lysyl Oxidases: Functions and Disorders - PubMed
Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize lysyl and hydroxylysyl residues in collagen and elastin, as a first step in the stabilization of these extracellular matrix proteins through the formation of covalent cross-linkages, an essential process for …
Lysyl oxidases: Emerging biomarkers and therapeutic targets for …
2020年11月1日 · The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes which initiate the covalent crosslinking of collagen and elastin fibers in the extracellular microenvironment, thereby facilitating extracellular matrix …
Lysyl oxidase: properties, regulation and multiple functions
Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin.
Lysyl Oxidase: Its Diversity in Health and Diseases - PMC
Lysyl oxidase (LOX) is an extracellular enzyme responsible for initiating covalent cross-link formation in collagen fibrils by oxidatively deaminating specific lysine and hydroxylysine residues to form allysines in the telopeptide domains of the collagen molecule [3].
Lysyl oxidase: properties, specificity, and biological roles inside …
2003年3月1日 · Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins.
Lysyl oxidase: Properties, regulation and multiple functions in …
1998年2月1日 · Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin.
Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM …
Lysyl oxidases (LOX) are a family of highly conserved copper-dependent enzymes comprising five members: lysyl oxidase (LOX) and four lysyl oxidase-like enzymes (LOXL1-4) . They were first discovered as a secreted extracellular matrix (ECM) modifying enzymes essential for crosslinking and stabilizing collagen and elastin fibers [ 1 ].
Lysyl Oxidase - an overview | ScienceDirect Topics
Lysyl oxidase is an extracellular matrix, copper – dependent amine oxidase that catalyzes a key enzymatic step in the crosslinking of collagen and elastin. The enzyme is synthesized as a propeptide that is cleaved by procollagen – C – proteinase into two distinct parts: the mature form and the LOX propeptide.
Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities …
Understanding the biology and mechanisms of all functions of each lysyl oxidase isoform is likely to provide significant therapeutic opportunities in addressing both cancer and fibrosis.
Lysyl oxidase: an oxidative enzyme and effector of cell function
2006年8月11日 · Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine residues to residues of α-aminoadipic-δ-semialdehyde.
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