CBL mutations drive PI3K/AKT signaling via increased interaction …
Apr 4, 2021 · We found that the CBL–LYN–phosphatidylinositol 3-kinase (PI3K) axis 26-29 plays a significant role in the gain-of-function phenotype conferred by CBL mutations. In addition, LYN inhibition by dasatinib effectively diminished the expansion of CBL -mutant cell lines and primary CMML samples in vitro and in vivo, highlighting the potential of ...
Lyn and Fyn function as molecular switches that control ... - Nature
Aug 15, 2017 · Our results demonstrate that Lyn is crucial to maintain ITAMi-mediated homeostasis, whereas Fyn is essential for ITAM-mediated cell activation by inducing the PI3K–PKCα signaling axis that ...
Src family kinases Fyn and Lyn are constitutively activated ... - Nature
Apr 3, 2017 · Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating residues are phosphorylated both before and after Toll-like receptor (TLR)...
CBL mutations drive PI3K/AKT signaling via increased ... - PubMed
Apr 22, 2021 · Genetic ablation or dasatinib-mediated inhibition of LYN reduced CBL phosphorylation, CBL-PIK3R1 interaction, and PI3K/AKT signaling. Furthermore, we demonstrated in vitro and in vivo antiproliferative efficacy of dasatinib in …
PI3K Signaling in Cancer: Beyond AKT - PMC - PubMed Central …
Production of PIP 3 from PI-4,5-P 2 by PI3K recruits BTK (via its PH domain) to the plasma membrane, where it can undergo activating phosphorylation by LYN and SYK. PI3K-dependent AKT activation also occurs in this context and regulates certain B-cell functions, but does not directly regulate BTK and is not discussed further here [ 69 ].
Blood：CBL突变通过强化LYN与PIK3R1相互作用驱动PI3K/AKT信 …
Jan 8, 2021 · cbl功能获得性突变与白介素敏感性和lyn与pi3k/ akt激活增强相关. lyn促进cbl-pik3r1互作、增强cbl突变细胞的增殖. 该研究分析表明， lyn激活增强和与突变型cbl的相互作用都是cbl突变细胞中cbl磷酸化增强、pik3r1募集和下游pi3k/ akt信号传导的关键驱动力 。cbl的信号衔接 …
New roles for B cell receptor associated kinases: when the B cell …
Jan 30, 2019 · Recently, studies using phospho-proteomics identified a crucial role of BCR signaling for the survival of Burkitt lymphoma (BL) cells, with highly phosphorylated levels of LYN, SYK, PI3K, and...
The phosphoinositide 3-kinase signaling pathway in normal and …
Aug 9, 2012 · The phosphoinositide 3-kinase (PI3K) pathway is a central signal transduction axis controlling normal B cell homeostasis and activation in humoral immunity. The p110δ PI3K catalytic subunit has emerged as a critical mediator of multiple B cell functions.
ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute ...
We evaluated the effects of PI3K and Lyn inhibition on the ACLY-mediated Acetyl-CoA and phospholipid synthesis, histone acetylation and growth of HL-60 AML cells. We report here a molecular mechanism in which both the substrate and product of PI3K, PIP 2 and PIP 3, respectively, directly bind to the Lyn tyrosine kinase-phosphorylated ACLY.
Lyn, a Src family kinase, regulates activation of epidermal growth ...
Jul 16, 2013 · Lyn, a Src family kinase functional in normal and malignant B-lymphocytes, was a defining signal transducer required for EGFR signaling in Calu3 cell line. Src family kinase activation in turn, was dependent on PKCßII. Lyn and PKC exist in membrane complexes of RACK1 and in association with EGFR which pairs with other receptor partners.
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