Love Sex Aur Dhokha 2 (LSD 2) is a 2024 Hindi-language anthology drama film written by Dibakar Banerjee, Shubham, Prateek Vats, and directed by Dibakar Banerjee. The film features Paritosh Tiwari, Bonita Rajpurohit, Abhinav Singh, and Swaroopa Ghosh in the lead roles. It is a sequel to the 2010 film of the same name. [3] .

Using short hairpin RNA, we stably knocked down LSD2 (LSD2-KD) in MDA-MB-231 breast cancer cells. LSD2-KD led to accumulation of H3K4me1/2 without changing methylation levels of other key histone lysine residues, suggesting that LSD2 acts as a bona fide H3K4 demethylase in breast cancer cells.

Lysine-specific demethylase 1 (LSD1) and its homolog, lysine-specific demethylase 2 (LSD2), are overexpressed in a variety of human cancer types and, thus, regulate tumour progression.

2022年3月17日 · Lysine-specific demethylase 1 (LSD1) and its homolog, lysine-specific demethylase 2 (LSD2), are overexpressed in a variety of human cancer types and, thus, regulate tumour progression.

In a high-tech world, three interwoven stories revolve around identity, online intimacy and the allure of social media. Watch trailers & learn more.

We reveal several novel findings: (1) an N-terminal peptide is essential for the nuclear localization of Lsd2; (2) Lsd1 and Lsd2 regulate each other; (3) the catalytic roles of Lsd1 and Lsd2 antagonize RNAi in heterochromatin formation; (4) Lsd1 and Lsd2 play roles in the maintenance and establishment of heterochromatin; and (5) Lsd1 and Lsd2 ...

2013年2月7日 · Here, we identify and characterize NPAC/GLYR1 as an LSD2/KDM1b-specific cofactor that stimulates H3K4me1 and H3K4me2 demethylation. We determine the crystal structures of LSD2 alone and LSD2 in complex with the NPAC linker region in the absence or presence of histone H3 peptide, at resolutions of 2.9, 2.0, and 2.25 Å, respectively.

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In this study, we conduct a comprehensive comparison between LSD2 and LSD1, with a focus on exploring LSD2’s implications. While both share structural similarities, LSD2 possesses unique features as well. Functionally, LSD2 shows diverse roles, particularly in cancer, with tissue-dependent roles.