
LPAR2 Gene - GeneCards | LPAR2 Protein | LPAR2 Antibody
2024年12月25日 · LPAR2 (Lysophosphatidic Acid Receptor 2) is a Protein Coding gene. Diseases associated with LPAR2 include Ovarian Cancer and Colorectal Cancer. Among its related pathways are PI3K-Akt signaling pathway and Nanog in Mammalian ESC Pluripotency.
Role of lysophosphatidic acid and its receptors in health and …
LPAR1 and LPAR2 signals through G αi, G αq, and G α12/13, which trigger several downstream signaling cascades through PLC, mitogen-activated protein kinases (MAPK), protein kinase B (PKB/Akt ...
LPAR2 lysophosphatidic acid receptor 2 [ (human)] - National …
LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-kappaB signaling to regulate cytokine network. Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.
LPAR2 correlated with different prognosis and immune cell …
2022年3月4日 · Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; however, the exact role of LPAR2 in tumors remains elusive. This study aims to explore the correlation between LPAR2 expression with tumor prognosis and immune infiltration in pan-cancers.
Lysophosphatidic Acid Receptors: Biochemical and Clinical …
LPAR1, LPAR2 and LPAR5 play essential roles in the invasion and metastasis of melanoma. Host LPA 1 and LPA 5 receptors promote B16F10 melanoma cell-derived lung metastasis. The expression of LPA 2 in tumor cells promotes invasion, but LPA 5 inhibits invasion.
Lysophosphatidic Acid Receptor Antagonists and Cancer: The …
LPAR2-Gi-Src-EGFR-ERK signaling cascade may mediate cell movement and LPA-stimulated COX-2 expression . Together with LPAR1, LPAR2 regulates phosphorylation of ezrin/radixin/moesin (ERM) proteins, known as membrane-cytoskeleton linkers, and leads to promotion of ovarian OVCAR-3 cancer cell migration through cytoskeletal reorganization and ...
LPAR2 correlated with different prognosis and immune cell …
2022年3月4日 · Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; however, the exact role of LPAR2 in tumors remains elusive. This study aims to explore the correlation between LPAR2 expression with tumor prognosis and immune infiltration in pan-cancers.
LPAR2 lysophosphatidic acid receptor 2 [ Homo sapiens (human) ]
2023年11月23日 · LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-κB signaling to regulate cytokine network. Wang Y, et al. J Cancer Res Clin Oncol, 2023 May. PMID 35857125. LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma.
A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in ...
2023年10月10日 · In this study, we investigated whether LPAR2 signaling was implicated in the development of NSAID-induced small intestinal injury (enteropathy), another major complication of NSAID use.
We conclude that LPAR2 has a dual role in NSAID enteropathy, as it contributes to the maintenance of mucosal integrity after NSAID exposure, but also orchestrates the in ammatory responses...
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