2024年12月25日 · LPAR2 (Lysophosphatidic Acid Receptor 2) is a Protein Coding gene. Diseases associated with LPAR2 include Ovarian Cancer and Colorectal Cancer. Among its related pathways are PI3K-Akt signaling pathway and Nanog in Mammalian ESC Pluripotency.

LPAR1 and LPAR2 signals through G αi, G αq, and G α12/13, which trigger several downstream signaling cascades through PLC, mitogen-activated protein kinases (MAPK), protein kinase B (PKB/Akt ...

LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-kappaB signaling to regulate cytokine network. Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.

2022年3月4日 · Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; however, the exact role of LPAR2 in tumors remains elusive. This study aims to explore the correlation between LPAR2 expression with tumor prognosis and immune infiltration in pan-cancers.

LPAR1, LPAR2 and LPAR5 play essential roles in the invasion and metastasis of melanoma. Host LPA 1 and LPA 5 receptors promote B16F10 melanoma cell-derived lung metastasis. The expression of LPA 2 in tumor cells promotes invasion, but LPA 5 inhibits invasion.

LPAR2-Gi-Src-EGFR-ERK signaling cascade may mediate cell movement and LPA-stimulated COX-2 expression . Together with LPAR1, LPAR2 regulates phosphorylation of ezrin/radixin/moesin (ERM) proteins, known as membrane-cytoskeleton linkers, and leads to promotion of ovarian OVCAR-3 cancer cell migration through cytoskeletal reorganization and ...

2022年3月4日 · Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; however, the exact role of LPAR2 in tumors remains elusive. This study aims to explore the correlation between LPAR2 expression with tumor prognosis and immune infiltration in pan-cancers.

2023年11月23日 · LPAR2-mediated action promotes human renal cell carcinoma via MAPK/NF-κB signaling to regulate cytokine network. Wang Y, et al. J Cancer Res Clin Oncol, 2023 May. PMID 35857125. LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma.

2023年10月10日 · In this study, we investigated whether LPAR2 signaling was implicated in the development of NSAID-induced small intestinal injury (enteropathy), another major complication of NSAID use.

We conclude that LPAR2 has a dual role in NSAID enteropathy, as it contributes to the maintenance of mucosal integrity after NSAID exposure, but also orchestrates the in ammatory responses...