Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A 2 enzyme that in humans is encoded by the PLA2G7 gene. [5][6] Lp-PLA 2 is a 45-kDa protein of 441 amino acids. [7] . It is one of several PAF acetylhydrolases.

2021年1月15日 · Lp-PLA2 is linked to the amount of plaque in the blood and can act as an early warning sign. Find out if you should test Lp-PLA2. Whether your Lp-PLA2 levels are normal, and what you can do to improve them. What is Lp-PLA2?

2020年1月1日 · The PLAC test is a blood test used to measure serum activity of lipoprotein-associated phospholipase A 2 (Lp-PLA 2), an enzyme that breaks down oxidized low-density lipoprotein in the...

se reactant. When disease is active in the artery, increased levels of Lp-PLA2 are produced by macrophages and foam cells within the intima of. the artery1. Lp-PLA2 also interacts with oxidized LDL, which increases inflammation and enhances a proatherogenic state, as well as plaque vu.

2021年12月20日 · LP-PLA2 is an enzyme chiefly associated with low density lipoprotein (LDL). LP-PLA2 is carried to the walls of the coronary artery by LDL where it plays a role in the inflammation of the blood vessels.

The PLAC® test for Lp-PLA 2 Activity is an enzyme assay for the in vitro quantitative determination of Lp-PLA 2 (lipoprotein-associated phospholipase A2) activity in EDTA plasma and serum.

2021年9月23日 · Lp-PLA2 is a biomarker released by immune cells specifically in blood vessels to cause inflammation. As vascular inflammation is associated with cardiovascular disease, measuring Lp-PLA2 levels is an accurate indicator of the risk of heart disease ¹ .

If you have Lp-PLA2 in your blood, you may have fatty deposits in your arteries that are at risk of rupturing and causing heart disease or stroke. This test may help your healthcare provider figure out what treatments would be best for you to prevent a stroke.

What is the PLAC® Test? The PLAC® Test measures the amount of Lp-PLA2 in the bloodstream. Lp-PLA2 is an enzyme that can assess the amount of inflammation in your arteries due to a build-up of cholesterol. Why should I get the PLAC® Test? The PLAC® Test can help assess your risk for heart disease or stroke.

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low-density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques.