In Caenorhabditis elegans, there is only one Lin28 gene that is expressed and in vertebrates, there are two paralogs present, Lin28a and Lin28b.

Dec 25, 2024 · LIN28A (Lin-28 Homolog A) is a Protein Coding gene. Diseases associated with LIN28A include Medulloepithelioma and Embryonal Tumor With Multilayered Rosettes, C19mc-Altered. Among its related pathways are Nervous system development and Transcriptional regulation of pluripotent stem cells.

Oct 26, 2021 · 在这里，作者提出强迫表达LIN28A作为一种调节细胞代谢的方法，进而提高自我更新，分化能力，并在移植后的各种人类SSCs的定植。 研究提高体细胞 干细胞 再生能力的方法是 再生医学 面临的重大挑战。 在这里，作者提出强迫表达 LIN28A 作为一种调节细胞代谢的方法，进而提高自我更新，分化能力，并在移植后的各种人类 SSCs 的定植。 在机制上，在未分化 / 增殖的 ssc 中， LIN28A 通过激活 pdk1 介导的糖酵解 - tca /OxPhos 解偶联，诱导从氧化磷酸化 …

LIN28A inhibitors, LIN28A-specific nanobodies, and deubiquitinases targeting LIN28A could be feasible options for cancer treatments while drugs upregulating LIN28A could be used in regenerative therapy for neuropathies. We will review the upstream and downstream signalling pathways of LIN28A and its physiological functions.

Mar 19, 2021 · The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression.

Feb 8, 2025 · LIN28A immunohistochemistry as a highly sensitive and specific, rapid, inexpensive diagnostic tool for routine pathological verification of embryonal tumor with multilayered rosettes. Lin28a is an appropriate cancer stem cell target molecule …

Feb 10, 2024 · Here, we show that the nucleolus-localized LIN28A protein undergoes liquid-liquid phase separation (LLPS) in mouse embryonic stem cells (mESCs) and in vitro. The RNA binding domains (RBD) and...

Oct 31, 2022 · Here, we identify a novel role for RNA-binding protein LIN28a, a master regulator of cellular metabolism in cardiac repair after injury. Methods: LIN28a overexpression was tested using mouse transgenesis on postnatal cardiomyocyte numbers, cell cycle, and response to apical resection injury.

Mar 27, 2022 · We will review the upstream and downstream signalling pathways of LIN28A and its physiological functions. Then, we will examine current research and gaps in research regarding its mechanisms in conditions such as cancers, liver diseases, and neurological diseases.

在人类恶性肿瘤细胞中，Lin28的激活能选择性地阻断原始let-7 miRNA的加工成熟并最终促进肿瘤的发生；Lin28在肿瘤疾病进程中的其他作用机制包括：通过抑制肿瘤相关microRNA的分化成熟、上调细胞周期相关基因的表达影响肿瘤的发展及预后。 另外，Lin28在肿瘤放化疗耐受相关研究中的重要作用日益凸显。 为此，本文对Lin28的相关生理功能和其在肿瘤发生发展的相关机制及治疗前景做一综述。 Abstract: Lin28 is a highly conserved RNA-binding protein that has an …