In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines the onset of early larval stages of developmental events in C. elegans, by regulating the self-renewal of nematode stem cells in the skin (called seam cells) and vulva (called VPCs) during development. [12] .

Jul 15, 2015 · LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7. However, recent studies have uncovered new roles for LIN28 and have revealed how it functions, suggesting that it is more than just a regulator of miRNA biogenesis.

Dec 25, 2024 · LIN28A (Lin-28 Homolog A) is a Protein Coding gene. Diseases associated with LIN28A include Medulloepithelioma and Embryonal Tumor With Multilayered Rosettes, C19mc-Altered. Among its related pathways are Nervous system development and Transcriptional regulation of pluripotent stem cells.

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and influence mRNA translation, thereby regulating the self-renewal of mammalian embryonic stem cells.

Mar 19, 2021 · The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression.

Mar 19, 2021 · The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although Lin28 blocks let-7 microRNA maturation, Lin28 also binds to a large set of cytoplasmic mRNAs directly.

Dec 15, 2023 · LIN28 proteins are proposed as diagnostic and/or prognostic markers for various cancers. LIN28 proteins play roles in multiple nervous system malignancies. Cancer and stem cells share many characteristics related to self-renewal and differentiation.