2024年12月25日 · LGALS9 (Galectin 9) is a Protein Coding gene. Diseases associated with LGALS9 include Dengue Virus and Echinococcosis . Among its related pathways are Cytokine Signaling in Immune system and Interleukin-2 family signaling .

2021年2月5日 · Here we show that PD-1 contributes to the persistence of PD-1 + TIM-3 + T cells by binding to the TIM-3 ligand galectin-9 (Gal-9) and attenuates Gal-9/TIM-3-induced cell death. Anti-Gal-9 therapy...

2023年11月1日 · Galectin-9 (LGALS9), a member of the galectin family, is a widely expressed protein involved in immune regulation and tumor pathogenesis, and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor cell survival through its interaction with its receptor Tim-3.

2014年8月21日 · Galectin-9 increased iTreg cell stability and function by directly binding to its receptor CD44, which formed a complex with transforming growth factor-β (TGF-β) receptor I (TGF-βRI), and activated Smad3. Galectin-9 signaling was further found to regulate iTreg cell induction by dominantly acting through the CNS1 region of the Foxp3 locus.

2018年8月17日 · Functionally, we find that Gal-9 is autologously produced by naive B cells, binds CD45, suppresses calcium signaling via a Lyn-CD22-SHP-1 dependent mechanism, and blunts B cell activation.

2022年6月4日 · Galectin-9 (LGALS9), a member of the galectin family, is a widely expressed protein involved in immune regulation and tumor pathogenesis, and affects the prognosis of various types of cancer. Galectin-9 regulates immune homeostasis and tumor cell survival through its interaction with its receptor Tim-3.

2014年8月21日 · Our data suggest that exogenous galectin-9, in addition to being an effector molecule for Treg cells, acts synergistically with TGF-β to enforce iTreg cell differentiation and maintenance. The role of Foxp3 + regulatory T (Treg) cells in immune tolerance and homeostasis has been extensively studied.

2019年1月1日 · Interest in Galectin 9 (LGALS9) is growing as this galectin has been identified as an immune checkpoint molecule. LGALS9 also supports leukemia stem cells (LSCs) though a mechanism of action is not clear.

LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux TIM-3 and its ligand, galectin-9 (Gal-9), constitute an autocrine loop critical for leukemic stem cells self-renewal and development of human acute myeloid leukemia.

2024年12月25日 · LGALS9C (Galectin 9C) is a Protein Coding gene. Diseases associated with LGALS9C include Splenic Manifestation Of Leukemia and Amelogenesis Imperfecta, Type Ie. Among its related pathways is TYROBP causal network in microglia. Gene Ontology (GO) annotations related to this gene include carbohydrate binding.