Three approaches to harness tumor suppressor miRNAs, such as let-7, for therapeutic purposes have been described, including: (1) the utilization of recombinant lentiviruses or adenoviruses expressing let-7 miRNAs in tumor cells as a type of gene therapy, (2) the administration of small molecules that epigenetically enhances endogenous let-7 ...

Oct 1, 2008 · let-7 remains one of the key miRNA regulators in development and cancer. The let-7-family miRNAs are highly conserved across animal species in sequence, at what developmental stage they are expressed and in their organization as clusters or within specific coding genes in …

Jun 1, 2015 · Here, we show that let-7b contributes to the maintenance of genomic balance via targeting Aurora B kinase, a key regulator of the spindle assembly checkpoint (SAC). Our results indicate that let-7b binds to Aurora B kinase 3′UTR reducing mRNA …

Jan 19, 2010 · Neural stem cell self-renewal and differentiation is orchestrated by precise control of gene expression involving nuclear receptor TLX. Let-7b, a member of the let-7 microRNA family, is expressed in mammalian brains and exhibits …

Jun 12, 2017 · We now report that let-7b and let-7c can positively regulate cellular H2Bub1 levels. Overexpression of let-7b and let-7c in a variety of non-transformed and cancer-derived cell lines...

Title: Exosomes derived from M1 macrophages inhibit the proliferation of the A549 and H1299 lung cancer cell lines via the miRNA-let-7b-5p-GNG5 axis. Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptors.

Nov 15, 2022 · Knockdown of let-7b in LAMs could inhibit the development of AML by repolarizing LAMs towards M1-subtype characteristics through the activation of Toll Like Receptor (TLR) and NF-κB pathway. Our study provides insight for future LAM-based immunotherapy strategies for …

We aimed to evaluate Sirtuin-1 mRNA and let-7b microRNA gene expression in breast cancer patients in Egypt and to relate them with clinicopathological features.

Additional characterization of let-7b induced miniature EPSCs (mEPSCs) in lamina IIo neurons of spinal cord slices. A and D, mEPCS traces showing the effects of 1-min perfusion of 7 µM of let-7b (A) and mutant oligos (D). The traces of (i) and (ii) are enlarged in bottom traces in short time scale. (B, C, E, F), quantification

Feb 16, 2024 · In this study, we found that let-7b-5p expression levels closely correlated with WHO grades and overall survival in patients in tumor glioma-CGGA-mRNAseq-325, and the upregulation of let-7b-5p can inhibit the proliferation and induce apoptosis of glioma cells.